Methods and compositions for enhanced delivery of macromolecules
AssigneeESBATech, an Alcon Biomedical Research Unit LLC
InventorsValerie Hulmann-Cottier, David Urech, Esther Furrer
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Abstract
The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10 kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.
Claims11
A method for selective intranasal delivery of an antigen-binding polypeptide to the central nervous system of a patient, the method comprising administering to a patient in need thereof a composition comprising a penetration enhancer and an antigen-binding protein, wherein the penetration enhancer is Pz-peptide.
The method of 2, wherein the scFv comprises a VH domain comprising an amino acid sequence with at least 80% similarity to SEQ ID No:
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- 10, or SEQ ID No:35.
Dependencies are inferred from the claim text.