Therapeutic Antibodies
OwnerHerman Waldmann, Mark Raymond Frewin +2inventors
InventorsHerman Waldmann, Mark Raymond Frewin, Lisa Kim Gilliland, Luis Richardo Simoes Da Silva Graca
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Abstract
A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
Claims21
1-34. (canceled)
A modified therapeutic antibody comprising a cell-binding antibody that includes an antibody combining site that binds to a cell-bound target antigen, said antibody being modified with a peptide that inhibits binding of the antibody to the target antigen, wherein the peptide comprises the target antigen or a domain or mimotope thereof which is reversibly bound to the antibody combining site of the antibody, said modified antibody being effective for reducing an immune response against the antibody and for producing a therapeutic effect by binding to the target antigen.
Dependencies are inferred from the claim text.