METHOD FOR INCREASING DEPOSITION OF COMPLEMENT C3b ON BACTERIAL SURFACE AND PHAGOCYTOSIS BY PHAGOCYTE AND A THERAPEUTIC METHOD AND A THERAPEUTIC AGENT FOR BACTERIAL INFECTIONS
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsSascha KRISTIAN, Mami KOYAMA, Yutaka KANDA, Tomoyuki TAHARA
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Abstract
The present invention relates to a method for increasing deposition of complement C3b on the bacterial surface and phagocytosis by phagocytes, a therapeutic method and a therapeutic agent for bacterial infections, using an antibody binding to a molecule on the bacterial surface, in which the antibody is modified by substituting at least one amino acid residue with other amino acid so as to show more enhanced complement-dependent cytotoxicity (CDC) than the antibody before substitution of the amino acid residue.
Claims11
A method for increasing deposition of complement C3b on the bacterial surface and phagocytosis by phagocytes using an antibody binding to a molecule on the bacterial surface, wherein the antibody is modified by substituting one or more amino acid residues with other amino acids so as to show more enhanced complement-dependent cytotoxicity (hereinafter, abbreviated to CDC) than the antibody before substitution of the amino acid residues.
A pharmaceutical composition for bacterial infections, comprising a pharmaceutically acceptable carrier and an antibody binding to a molecule on the bacterial surface, which is modified by substituting one or more amino acid residues with other amino acids so as to show more enhanced CDC than the antibody before substitution of the amino acid residues as an active agent.
A therapeutic method for bacterial infections, characterized in that an antibody binding to a molecule on the bacterial surface, which is modified by substituting one or more amino acid residues with other amino acids so as to show more enhanced CDC than the antibody before substitution of the amino acid residues, is used to increase deposition of complement C3b on the bacterial surface and phagocytosis by phagocytes, thereby reducing bacterial proliferation.
Dependencies are inferred from the claim text.