Treatment of obesity
AssigneeIsis Innovation Limited
InventorsAmany ELSHORBAGY, Helga Margareta REFSUM
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Abstract
The present disclosure relates to the treatment, e.g. reduction, of body fat mass levels for example in overweight and obese subjects. The present disclosure also relates to weight control in a subject where obesity should be avoided. Disclosed herein are methods of reducing body fat mass e.g. reducing obesity or preventing weight gain and agents used in such methods whereby the agents inhibit a sulphur containing amino acid. Also included in the present disclosure include, without being limited to, methods for determining regimes for the treatment of obesity as well as other subject matter.
Claims26
-45. (canceled)
A method of decreasing, or controlling, the amount of body fat mass in a subject at risk of, or requiring treatment for, being overweight or obese comprising administering a composition comprising an agent to said subject to inhibit or reduce the level of cysteine.
A method of decreasing, or controlling, the amount of body fat mass in a subject at risk of, or requiring treatment for, being overweight or obese comprising administering a composition comprising mesna to said subject to inhibit or reduce the level of cysteine.
A method of predicting an increase in a subject's body fat mass comprising measuring the subject's plasma cysteine concentration, wherein a high cysteine concentration is associated with an increased risk of an increase in the subject's body fat mass.
A method of screening for an agent for the treatment of obesity comprising:
- a. administering a test agent to an animal;
- and
- b. detecting the plasma concentration of one or more sulphur containing amino acids.
Dependencies are inferred from the claim text.