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US 2014/0212381 A1Published application
Macrocycles
AssigneeScynexis, Inc.
InventorsKeqiang Li, Michael Robert Peel
Life of this patent
Estimating the term…
Abstract
Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
Claims12
A cyclosporine A derivative in which the 3-Sarcosine position is substituted by a group —S—CH2C[CH2(CH2)n]NR2R3, wherein R2 is hydrogen or an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms, the chain is straight or branched;
- R3 is an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms the chain is straight or branched;
- and n is 1 or 2.
Dependencies are inferred from the claim text.