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AssigneesUniversite Libre de Bruxelles, Centre Hospitalier Universitaire De Liege, Universite De Liege, Bone Therapeutics S.A.
InventorsValerie Gangji, Jean-Philippe Hauzeur, Dominique De Seny, Myrielle Mathieu, Aude Ingels, Sabrina Rigutto, Delphine Spruyt, Enrico Bastianelli, Valentina Albarani, Xavier Pesesse, Michel Malaise
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The application teaches a composition comprising one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8 or CXCL8), a functional fragment of IL-8, a functional variant of IL-8, and an agonist of IL-8 receptor, for therapeutic and/orprophylactic interventions in impaired bone fracture healing, such as but not limited to non-union fractures, mal-union fractures, or delayed union fractures.
A method of treating impaired bone fracture healing, the method comprising a step of administering one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8), a functional fragment of IL-8, a functional variant of IL-8, and an agonist of IL-8 receptor.
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