The controlled release method for a pharmaceutical composition composed of chelating complex micelles
AssigneeOriginal Biomedicals Co., Ltd
InventorsChia-Hung Chen, Chau-Hui Wang, John-Son Lin, Tieh-Hsiung Chiu, Jing-Yi Chen, Pi-Hung Liao, Chia-Chi Su, Wei-Chuan Liao
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Abstract
This invention provides the controlled-release method for a pharmaceutical composition comprising of metals in the drug carrier. The specific chelator is used to trigger the release of active pharmaceutical ingredients from chelating complex micelles. The drug release rate and half-life can also be controlled by manipulating the dosing sequence and the concentration of metal and specific chelator.
Claims11
A controlled-release method for manipulating drug release, comprising administrations of:
- a chelating complex micelles comprise at least a drug molecule, a polymer ligand, and a metal core;
- and
- at least one selected from:
- a metal chelator, wherein corresponds to the metal core of chelating complex micelles, and
- a metal, wherein as the same as the metal core of the chelating complex micelles.
A controlled-release method using chelating complex micelles, comprising administrations of:
- a chelating complex micelles containing ferrous ion and embedded drug,
- wherein the drug is amifostine, vancomycin, ciprofloxacin, doxorubicin, or epirubicin;
- and
- deferoxamine is administered 0.1 to 24 hours post administration of the chelating complex micelles.
Dependencies are inferred from the claim text.