Nanoparticles for the treatment of radiation skin injury

A method of evaluating platelet function in vivo using skin-irradiation and nanoparticle radiation treatment, said method comprising the steps of:

• a) providing submicron nanoparticles;
• b) providing a platelet treatment product;
• c) administering intravenously to at least one first non-thrombocytopenic subject a predetermined dose of the submicron nanoparticles;
• d) administering intravenously to at least one second non-thrombocytopenic subject a predetermined dose of the platelet treatment product;
• e) irradiating the first and second non-thrombocytopenic subjects to produce radiation skin injury on at least a portion of the first and second non-thrombocytopenic subjects;
• f) determining an amount of radiation skin injury on the portion of the first and second non-thrombocytopenic subjects;
• g) comparing the amount of radiation skin injury between the first and second non-thrombocytopenic subjects;
• and
• j) evaluating an effectiveness of the platelet treatment product on platelet function in vivo.