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US 2014/0212355 A1Published application
Trans-arterial drug delivery
AssigneeAbbott Cardiovascular Systems Inc.
InventorsMikael TROLLSAS, Syed Hossainy, John Stankus, Paul Consigny
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Abstract
It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers.
Claims24
A method of treating a liver cancer in a subject in need thereof comprising:
- deploying a bioresorbable polymer scaffold in the lumen of a blood vessel that directly services a diseased liver or a cancer tissue therein,
- wherein the bioresorbable polymer scaffold comprises a polymer substrate and optionally a coating upon the substrate, wherein a first therapeutic agent is embedded or impregnated in the substrate, the coating if present, or both,
- wherein a therapeutically effective amount of the first therapeutic agent is released from the scaffold upon the deployment thereof over a period of time;
- wherein the first therapeutic agent is an anti-angiogenesis agent.
1 more element
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A drug eluting device comprising:
- a bioabsorbale polymer scaffold which comprises a polymer substrate and optionally a coating upon the substrate,
- a first therapeutic agent which is an anti-angiogenesis agent selected from the group consisting of an anti-VEGF antibody, an anti-EGFR antibody, a small molecule anti-angiogenesis drug, and any combination thereof;
- optionally a second therapeutic agent selected from the group consisting of anti-proliferative agents, anti-inflammatory agents, and anti-neoplastic agent;
- wherein the therapeutic agents are incorporated either in the polymeric substrate or the coating if present or both.
1 more element
The drug eluting device of claim 21, which is a stent.
24-45. (canceled)
Dependencies are inferred from the claim text.