Valproic acid biosensor and method for measuring concentration of valproic acid
AssigneeNational Taiwan University
InventorsLong-Sun Huang, Kai-Fung Chang, Yu-Chen Chang
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Abstract
The present disclosure relates to a valproic acid biosensor. In some embodiments, the valproic acid biosensor may comprise a microcantilever, a self-assembly monolayer, and a valproic acid antibody layer. The self-assembly monolayer may immobilize on the microcantilever surface. The valproic acid antibody layer may immobilize on the self-assembly monolayer. The valproic acid antibody layer may be used to bind with valproic acid drug samples. The present disclosure further relates to methods for measuring the concentration of valproic acid drug samples.
Claims16
A valproic acid biosensor comprising:
- a microcantilever;
- a self-assembly monolayer immobilized on the microcantilever;
- and
- a valproic acid antibody layer immobilized on the self-assembly monolayer, the valproic acid antibody layer operable to binding with valproic acid drug samples.
A method for measuring a concentration of valproic acid, comprising:
- manufacturing a microcantilever having a piezoresistive layer;
- binding a plurality of self-assembly molecules to the microcantilever;
- activating the bonded self-assembly molecules;
- binding a plurality of valproic acid antibodies with the activated self-assembly molecules;
- binding a plurality of valproic acid drug samples with the valproic acid antibodies;
- measuring a change of resistance of the piezoresistive layer;
- and
- calculating the concentration of the valproic acid according to a pre-determined relationship between the measured resistance change and the concentration of the valproic acid drug samples.
A method for measuring a concentration of valproic acid, comprising:
- manufacturing a microcantilever having a field effect transistor;
- binding a plurality of self-assembly molecules to the microcantilever;
- activating the bonded self-assembly molecules;
- binding a plurality of valproic acid antibodies with the activated self-assembly molecules;
- binding a plurality of valproic acid drug samples with the valproic acid antibodies;
- measuring a change of current of the field effect transistor;
- and
- calculating the concentration of valproic acid according to a pre-determined relationship between the measured current change and the concentration of the valproic acid drug samples constructed previously.
Dependencies are inferred from the claim text.