# US 2014/0208464 A1 · Delivery of viral agents > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0208464 A1 - Document ID: US20140208464A1 - Status: Published application - Kind: A1 - Application number: 14/127,429 - Filed: 2012-06-25 - Published: 2014-07-24 - Earliest claimed: 2011-06-23 - Assignees: Fixed Phage Limited - Inventors: James Chadwick; Michael Mattey - Web page: https://patentgrep.com/patent/US20140208464A1 ## CPC - A61K 35/76: Viruses; Subviral particles; Bacteriophages - A01N 37/46: N-acyl derivatives - A01N 63/40: Viruses, e.g. bacteriophages - A23K 10/10: obtained by microbiological or biochemical processes (using chemicals or microorganisms for ensilaging of green fodder A23K30/15) - A23K 10/18: of live microorganisms - A23K 10/30: from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms (obtained by microbiological or biochemical processes, e.g. using yeasts or enzymes, A23K10/10) - A23K 50/70: for birds - A23K 50/75: for poultry - A61K 35/768: Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766 - A61L 15/36: containing microorganisms - A61L 15/44: Medicaments - A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system - A61P 31/04: Antibacterial agents - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/442: Colorants, dyes - C12N 2795/00032: Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A23K: FODDER - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) ## Abstract Plant material has bacteriophage has been attached, wherein the bacteriophage retains infectivity. The plant material includes fruits, vegetables, leaves, stems, flowers, roots, tubers, seedlings and seeds. Plant diseases and animal diseases can be treated. A separate composition comprises a carrier selected from (i) a filament, (ii) a planar material, and (iii) particles and/or beads, and bacteriophage covalently attached thereto, wherein the bacteriophage retains infectivity, useful in treatment or prevention of bacterial infection in a deep wound. ## Claims ### Claim at position 1 -39. (canceled) ### Claim 40 Plant material, selected from seeds, roots and tubers, to which bacteriophage has been covalently attached, wherein the bacteriophage is attached to the plant material by activating the plant material and then attaching the bacteriophage to the activated plant material, and wherein the bacteriophage retains infectivity. ### Claim 41 (depends on 40) The plant material of claim 40, being seeds for consumption or seed stock. ### Claim 42 (depends on 40) The plant material of claim 40, being tomato seeds. ### Claim 43 (depends on 40) The plant material of claim 40, for prevention or treatment of a plant disease. ### Claim 44 (depends on 40) The plant material of claim 40, for prevention or treatment of a disease in a creature that eats the plant material. ### Claim 45 (depends on 40) The plant material of claim 40, for prevention or treatment of bacterial infections in the gastrointestinal tract. ### Claim 46 (depends on 40) The plant material of claim 40, for prevention or treatment of avian disease. ### Claim 47 (depends on 40) The plant material of claim 40, wherein the bacteriophage is covalently attached to a particle and the particle is covalently attached to the plant material. ### Claim 48 A method of treating plant material selected from seeds, roots and tubers, comprising activating the plant material and then covalently attaching the bacteriophage to the activated plant material, wherein the bacteriophage retains infectivity. ### Claim 49 (depends on 48) The method of claim 48, wherein the plant material comprises seeds for consumption or seed stock. ### Claim 50 (depends on 48) The method of claim 48, wherein the plant material is for prevention or treatment of a plant disease. ### Claim 51 (depends on 48) The method of claim 48, comprising covalently attaching the bacteriophage to a particle or particles and covalently attaching the particle or particles to the plant material. ### Claim 52 A method of treating plant material for use in treating or preventing a disease in a creature that eats the plant material, wherein the plant material is selected from fruits, vegetables, leaves, stems, flowers, roots, tubers and seedlings, comprising combining an aqueous preparation of particles to which bacteriophage are covalently attached with the plant material and drying the combination to attach the particles to the plant material. ### Claim 53 (depends on 40) A composition comprising the plant material of claim 40. ### Claim 54 (depends on 53) A method of preventing or treating disease in a creature that eats plant material, comprising administrating to the creature the composition of claim 53. ### Claim 55 (depends on 54) The method of claim 54, wherein the disease is a gastrointestinal disease. ### Claim 56 A composition comprising: a) a carrier selected from (i) a filament, (ii) a planar material, (iii) particles and (iv) beads, and b) bacteriophage covalently attached to the carrier of (a) for use in treatment or prevention of bacterial infection in a deep wound, wherein the composition is located in a deep wound which is then closed up, and wherein the bacteriophage retains infectivity. ### Claim 57 (depends on 56) The composition of claim 56, wherein the carrier is biodegradable or biocompatible or biodegradable and biocompatible. ### Claim 58 (depends on 56) The composition of claim 56, wherein the carrier is tissue compatible and can be absorbed in situ. ### Claim 59 (depends on 56) A method of treatment of infection at a site in the body, comprising locating a composition of claim 56 in wound and then closing the wound.