Methods and materials for reducing the severity of viral infections
AssigneeMayo Foundation for Medical Education and Research
InventorsMoses Rodriguez, Allan J. Bieber, Arthur E. Warrington, JR., Meghan McGee Painter
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Abstract
This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.
Claims13
A method for increasing expression of a set of nucleic acids encoding polypeptides involved in innate immunity within a mammal, wherein said method comprises administering a lentiviral vector comprising nucleic acid encoding a picornavirus 3Dpol polypeptide or a fragment thereof to said mammal under conditions wherein said expression of said set of nucleic acids is increased, wherein said polypeptides involved in innate immunity comprise an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide.
A method for increasing expression of a set of nucleic acids encoding polypeptides involved in innate immunity within a mammal, wherein said method comprises administering a composition comprising RNA encoding a picornavirus 3Dpol polypeptide or a fragment thereof to said mammal under conditions wherein said expression of said set of nucleic acids is increased, wherein said polypeptides involved in innate immunity comprise an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide.
Dependencies are inferred from the claim text.