# US 2014/0197044 A1 · Measuring nitric oxide in fluid > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0197044 A1 - Document ID: US20140197044A1 - Status: Published application - Kind: A1 - Application number: 14/155,346 - Filed: 2014-01-14 - Published: 2014-07-17 - Earliest claimed: 2013-01-14 - Assignees: LifeHealth, LLC - Inventors: Scott Everett BLOMBERG; Mark Louis Peterson; Amanda Marie Franey - Web page: https://patentgrep.com/patent/US20140197044A1 ## CPC - G01N 33/0011: {Sample conditioning (preparing specimens for investigation G01N1/28)} - G01N 33/0037: {NOx} - Y02A 50/20: Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract Apparatus and methods in accordance with one or more preferred embodiments of the present invention are used to measure nitric oxide in a fluid, and each includes a sample injection port; a pump; a measurement chamber; an electromagnetic radiation source; one or controls and user interfaces; and a cartridge. The cartridge includes a sample chamber; an electromagnetic radiation and heat chamber; and a gas permeable membrane. The cartridge preferably is single-use and disposable. Further apparatus and methods in accordance with other alternative embodiments, and additional inventive aspects and features, are disclosed related to measuring nitric oxide in a fluid. ## Claims ### Claim 1 A method for measuring a dissolved gas in a fluid comprising the steps of: liberating the dissolved gas from the fluid; capturing the liberated gas in a carrier gas; and measuring the dissolved gas concentration using an electrochemical sensor. ### Claim 2 (depends on 1) The method of claim 1 wherein the dissolved gas is nitric oxide. ### Claim 3 (depends on 1) The method of claim 1, wherein the method of liberating the dissolved gas from the fluid includes the steps of: freeing the gas from its molecular bonds using electromagnetic radiation; and outgassing the dissolved gas from the fluid. ### Claim 4 (depends on 3) The method of claim 3, wherein the electromagnetic radiation is generated using a light emitting diode. ### Claim 5 (depends on 3) The method of claim 3, wherein the outgassing method is by heat vaporization. ### Claim 6 (depends on 1) The method of claim 1, wherein the method for capturing the liberated gas is closed from ambient atmosphere. ### Claim 7 An apparatus for measuring nitric oxide in a fluid, comprising: a disposable component for containing liquid or solid residue from a fluid sample; and a reusable instrument component comprising a pump, one or more valves, a nitric oxide sensor, one or more controls and one or more user interfaces. ### Claim 8 (depends on 7) The apparatus of claim 7, wherein the disposable component is designed for a single use. ### Claim 9 (depends on 7) The apparatus of claim 7, wherein the disposable component contains means for liberating nitric oxide gas from the fluid. ### Claim 10 (depends on 9) The apparatus of claim 9, wherein the means for liberating nitric oxide gas from the fluid includes an electromagnetic radiation source. ### Claim 11 (depends on 9) The apparatus of claim 9, wherein the means for liberating nitric oxide gas from the fluid comprises a means for outgassing the nitric oxide gas from the fluid. ### Claim 12 (depends on 7) The apparatus of claim 7, wherein the one or more controls and one or more user interfaces comprises a microprocessor. ### Claim 13 (depends on 7) The apparatus of claim 7, wherein the sensor for measuring nitric oxide gas is an electrochemical sensor. ### Claim 14 (depends on 7) The apparatus of claim 7, wherein the apparatus includes a means for capturing the nitric oxide containing gas. ### Claim 15 (depends on 14) The apparatus of claim 14, wherein the means for capturing the nitric oxide containing gas is closed to ambient atmosphere. ### Claim 16 (depends on 10) The apparatus of claim 10 wherein the instrument includes the electromagnetic radiation source. ### Claim 17 (depends on 16) The apparatus of claim 16 wherein the electromagnetic radiation source comprises one or more light emitting diodes. ### Claim 18 (depends on 7) The apparatus of claim 7, wherein the disposable component includes a means for containing the liquid and solid components of the fluid sample. ### Claim 19 (depends on 18) The apparatus of claim 18, wherein the means for containing the liquid and solid components of the fluid sample is a gas permeable membrane. ### Claim 20 An apparatus for measuring nitric oxide in a fluid, comprising: a gas pump; a valve; a measurement chamber; an electromagnetic radiation source; a heater; control and user interface; and a cartridge comprising a sample chamber, a sample degassing chamber, and a reaction chamber. ### Claim 21 An apparatus for measuring nitric oxide in a fluid, comprising: a sample injection port; a pump and reservoir; a valve; a measurement chamber; an electromagnetic radiation source; control and user interface; and a cartridge comprising a sample chamber, a mix chamber, a sample degassing chamber, and a planar reaction chamber. ### Claim 22 (depends on 21) The apparatus of claim 21, wherein the cartridge is disposable and is designed for a single use. ### Claim at position 23 23-24. (canceled)