# US 2014/0194987 A1 · Silk covered breast implant

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- Number: US 2014/0194987 A1
- Document ID: US20140194987A1
- Status: Published application
- Kind: A1
- Application number: 14/170,242
- Filed: 2014-01-31
- Published: 2014-07-10
- Earliest claimed: 2009-04-20
- Assignees: Allergan, Inc.
- Applicants: Allergan, Inc.
- Inventors: Gregory H. Altman; Rebecca L. Horan; Adam L. Collette; Jingsong Chen; Dennis Van Epps
- Web page: https://patentgrep.com/patent/US20140194987A1

## CPC

- A61F 2/12: Mammary prostheses
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 38/1767: {from invertebrates}
- A61K 47/42: Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34)
- A61L 27/227: {Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24}
- A61L 27/26: Mixtures of macromolecular compounds
- A61L 27/52: Hydrogels or hydrocolloids
- A61P 9/06: Antiarrhythmics
- A61P 17/00: Drugs for dermatological disorders
- A61P 23/02: Local anaesthetics
- A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 19/00: Preparations for care of the skin
- C08B 37/0072: {Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates}
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K 2800/91: Injection
- A61L 2430/34: for soft tissue reconstruction
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)

## Abstract

The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

## Claims

### Claim 1

A breast implant partially or completely covered with silk.

### Claim 2 (depends on 1)

The breast implant of claim 1, wherein the silk is silk fibroin.

### Claim 3 (depends on 2)

The breast implant of claim 2, wherein the silk is a silk fibroin hydrogel.

### Claim 4 (depends on 3)

The breast implant of claim 3, wherein the silk fibroin hydrogel provides a beneficial interface with host tissue and reduces the potential for malpositioning or capsular contracture.

### Claim 5 (depends on 4)

The breast implant of claim 4, wherein the silk fibroin hydrogel is present as a wrap-like configuration on a silicone filled breast implant used in breast reconstruction or breast augmentation surgery.