# US 2014/0194974 A1 · Implantable medical device having enhanced endothelial migration features and methods of making the same

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- Number: US 2014/0194974 A1
- Document ID: US20140194974A1
- Status: Published application
- Kind: A1
- Application number: 14/156,017
- Filed: 2014-01-15
- Published: 2014-07-10
- Earliest claimed: 2011-05-09
- Assignees: Palmaz Scientific, Inc.
- Applicants: Palmaz Scientific, Inc.
- Inventors: Julio C. Palmaz
- Web page: https://patentgrep.com/patent/US20140194974A1

## CPC

- A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)}
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F 2/90: characterised by a net-like or mesh-like structure
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/01: Filters implantable into blood vessels
- A61F 2/06: Blood vessels
- A61F 2/24: Heart valves {; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body}
- A61F 2230/0017: Angular shapes
- A61F 2230/0026: trapezoidal
- A61F 2230/0056: W-shaped, e.g. M-shaped, sigma-shaped
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0051: differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
- Y10T 29/49: Method of mechanical manufacture
- Y10T 29/49826: Assembling or joining
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.

## Claims

### Claim 1

An implantable medical device having enhanced endothelial migration features, comprising:
a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.

### Claim 2 (depends on 1)

The implantable medical device of claim 1, wherein the shear stress generated at the second surface region between about 5 and 25 dynes/cm2.

### Claim 3 (depends on 1)

The implantable medical device of claim 1, wherein the second surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm.

### Claim 4 (depends on 3)

The implantable medical device of claim 3, wherein the second surface region joins a first edge to form an angle As, wherein the angle As is less than 90 degrees.

### Claim 5 (depends on 4)

The implantable medical device of claim 4, wherein second surface region joins the third surface region to an angle At, wherein the angle At is greater than 90 degrees.

### Claim 6 (depends on 5)

The implantable medical device of claim 5, wherein the length of the third surface region is less than the length of the second surface region.

### Claim 7 (depends on 6)

The implantable medical device of claim 6, wherein the first edge joins a second edge and the second edge joins a third edge, whereby the third edge joins the trailing edge to form a substantially hexagonal cross-section configuration of the structural member.

### Claim 8 (depends on 7)

The implantable medical device of claim 7, wherein the fourth surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm.

### Claim 9 (depends on 8)

The implantable medical device of claim 8, wherein the fourth surface region joins the third edge to form an angle Ar, wherein the angle Ar is less than 90 degrees.

### Claim 10 (depends on 9)

The implantable medical device of claim 9, wherein fourth surface region joins the third surface region to an angle As, wherein the angle As is greater than 90 degrees.

### Claim 11 (depends on 10)

The implantable medical device of claim 10, wherein the length of the third surface region is less than the length of the fourth surface region.

### Claim 12 (depends on 11)

The implantable medical device of claim 11, wherein the second surface region and the fourth surface region includes a plurality of geometric physiologically functional features including a focal adhesion point for affinity binding of endothelial cells.

### Claim 13 (depends on 11)

The implantable medical device of claim 11, wherein the leading edge and the trailing edge includes a plurality of grooves disposed thereon.

### Claim 14

A method of forming an implantable medical device having enhanced endothelial migration features, comprising:
forming a structural member including a leading edge and a trailing edge interconnected by a third surface region,
forming the leading edge to include a second surface region in a generally curvilinear cross-section,
and forming the trailing edge to include a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.

### Claim 15 (depends on 14)

The method of claim 14, further comprising forming the second surface region to include includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm.

### Claim 16 (depends on 15)

The method of claim 15, further comprising joining the second surface region to a first edge to form an angle As, wherein the angle As is less than 90 degrees.

### Claim 17 (depends on 16)

The method of claim 16, further comprising joining the second surface region to the third surface region at an angle At, wherein the angle At is greater than 90 degrees.

### Claim 18 (depends on 17)

The method of claim 17, further comprising joining the first edge to a second edge and joining the second edge to a third edge, whereby the third edge joins the trailing edge to form a substantially hexagonal cross-section configuration of the structural member.

### Claim 19 (depends on 18)

The method of claim 18, wherein the fourth surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm.

### Claim 20 (depends on 19)

The method of claim 19, further comprising joining the fourth surface region to the third edge to form an angle Ar, wherein the angle Ar is less than 90 degrees.