# US 2014/0194830 A1 · Assembly for a drug delivery device, piston rod and drug delivery device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194830 A1 - Document ID: US20140194830A1 - Status: Published application - Kind: A1 - Application number: 14/191,757 - Filed: 2014-02-27 - Published: 2014-07-10 - Earliest claimed: 2010-08-06 - Assignees: Sanofi-Aventis Deutschland GmbH - Applicants: Sanofi-Aventis Deutschland GmbH - Inventors: Philippe Nzike; Steffen Raab; Uwe Dasbach; Uwe Boeser; Ulrich Brüggemann; Francisco Soares - Web page: https://patentgrep.com/patent/US20140194830A1 ## CPC - A61M 5/31536: {Blocking means to immobilize a selected dose, e.g. to administer equal doses} - A61M 5/31525: {Dosing (burettes, pipettes B01L3/02)} - A61M 5/31541: {Means preventing setting of a dose beyond the amount remaining in the cartridge} - A61M 5/31551: {including axial movement of dose setting member} - A61M 5/31585: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button} - A61M 5/24: Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic - A61M 5/31543: {piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change} - A61M 5/31593: {Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract An assembly for a drug delivery device, comprising: a housing having a distal end and a proximal end, a piston rod, a drive member, the drive member being moveable in a proximal direction with respect to the housing and with respect to the piston rod for setting a dose of a drug, at least one stop member which is provided on one of the piston rod and the drive member and which is radially moveable with respect to the one of the piston rod and the drive member on which it is provided, and at least one interaction member which is provided on the other one of the piston rod and the drive member. Furthermore, a piston rod for a drug delivery device is provided. ## Claims ### Claim 1 An assembly for a drug delivery device, comprising: a housing having a distal end and a proximal end, a piston rod, a drive member, the drive member being moveable in a proximal direction with respect to the housing and with respect to the piston rod for setting a dose of a drug, at least one stop member which is provided on one of the piston rod and the drive member and which is radially moveable with respect to the one of the piston rod and the drive member on which it is provided, at least one interaction member which is provided on the other one of the piston rod and the drive member, wherein, in a non-locking mode of the assembly, the stop member is radially biased, and the stop member and the interaction member are arranged axially spaced apart from each other by an axial distance, the axial distance being reduced by a dosing distance when the drive member is moved in the proximal direction, and wherein, when the dosing distance corresponds to the axial distance, the assembly is configured to switch into a locking mode, wherein, for switching into the locking mode, the radial bias of the stop member is permitted to decrease at least partially to bring the stop member and the interaction member in mechanical cooperation, wherein, when the stop member and the interaction member mechanically cooperate, the stop member and the interaction member are configured to axially interlock the piston rod and the drive member such that, in the locking mode, movement of the drive member in the proximal direction with respect to the piston rod is prevented. ### Claim 2 (depends on 1) The assembly according to claim 1, wherein the stop member comprises a resilient member or a resiliently mounted member, and wherein the interaction member comprises at least one cavity. ### Claim 3 (depends on 1) The assembly according to claim 1, wherein, if the at least one stop member is provided on the piston rod, the stop member is biased radially outwardly with respect to the housing when the assembly is in the non-locking mode, and wherein, if the at least one stop member is provided on the drive member, the stop member is biased radially inwardly with respect to the housing when the assembly is in the non-locking mode. ### Claim 4 (depends on 1) The assembly according to claim 1, wherein the assembly comprises a dose member, and, in the non-locking mode, the dose member is displaceable in the proximal direction with respect to the housing and with respect to the piston rod for setting the dose and displaceable in the distal direction with respect to the housing and with respect to the piston rod for correcting the set dose, wherein the drive member is arranged to follow displacement of the dose member with respect to the housing and with respect to the piston rod for setting and for correcting the dose. ### Claim 5 (depends on 4) The assembly according to claim 4, wherein the dose member is rotatable with respect to the housing, and wherein the dose member and the drive member are adapted to be releasably coupled to one another via a clutch connection, wherein, when the dose member and the drive member are decoupled, the dose member is rotatable with respect to the drive member for setting or correcting the dose, and wherein, when the dose member and the drive member are coupled, rotational movement of the dose member is converted into rotational movement of the drive member with respect to the housing. ### Claim 6 (depends on 5) The assembly according to claim 5, comprising a spring member which is adapted and arranged to keep the drive member and the dose member decoupled to permit relative rotational movement of the dose member and the drive member for setting or correcting the dose. ### Claim 7 (depends on 1) The assembly according to claim 1, wherein the piston rod comprises a thread which is flattened in at least one axially extending portion and the drive member comprises at least one flattened portion provided axially along the inner surface of the drive member, wherein the piston rod is splined to the drive member by mechanical cooperation of the flattened inner portion and the flattened axially extending portion of the thread. ### Claim 8 (depends on 1) The assembly according to claim 1, wherein, in the locking mode, a dose setting action of the assembly is prevented due to mechanical cooperation of the stop member and the interaction member, and wherein, in the locking mode, the piston rod and the drive member are releasably axially interlocked by mechanical cooperation of the interaction member and the stop member such that a dose correction action of the assembly is enabled in the locking mode. ### Claim 9 (depends on 8) The assembly according to claim 8, wherein the interaction member comprises an oblique side face arranged in a proximal end section of the interaction member, the oblique side face being adapted and arranged to allow movement of the drive member in the distal direction with respect to the piston rod for correcting the set dose in the locking mode. ### Claim 10 (depends on 8) The assembly according to claim 8, wherein, when the drive member is moved in the distal direction with respect to the piston rod for correcting the set dose starting from the locking mode, the assembly is switched from the locking mode back into the non-locking mode. ### Claim 11 (depends on 1) The assembly according to claim 1, wherein, in the locking mode, the piston rod and the drive member are permanently axially interlocked by mechanical cooperation of the interaction member and the stop member such that a dose setting and a dose correction action is prevented in the locking mode. ### Claim 12 (depends on 1) The assembly according to claim 1, comprising a dose button, wherein the drive member and the dose button are adapted to be coupled to one another by a uni-directional rotational coupling, the uni-directional rotational coupling being configured to permit rotational movement of the drive member with respect to the dose button in one rotational direction when delivering the set dose and to prevent rotational movement of the drive member with respect to the dose button in the opposite rotational direction. ### Claim 13 (depends on 5) The assembly according to claim 5 further comprising a dose button, wherein the drive member and the dose button are adapted to be coupled to one another by a uni-directional rotational coupling, the uni-directional rotational coupling being configured to permit rotational movement of the drive member with respect to the dose button in one rotational direction when delivering the set dose and to prevent rotational movement of the drive member with respect to the dose button in the opposite rotational direction, wherein the dose button is configured to be pushed for delivering the set dose such that the dose button is displaced in the distal direction with respect to the dose member for coupling the dose member and the drive member by the clutch connection. ### Claim 14 (depends on 1) A drug delivery device comprising the assembly according to claim 1 and a cartridge, the cartridge holding a plurality of doses of a drug, wherein the assembly provides an end-stop mechanism preventing setting of a dose of the drug exceeding the dispensable quantity of the drug held in the cartridge. ### Claim 15 A piston rod for a drug delivery device, comprising a resiliently mounted member arranged in a proximal end section of the piston rod, the resiliently mounted member being radially moveable with respect to the piston rod.