# US 2014/0194808 A1 · Methods and systems for use of photolyzable nitric oxide donors > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194808 A1 - Document ID: US20140194808A1 - Status: Published application - Kind: A1 - Application number: 14/148,524 - Filed: 2014-01-06 - Published: 2014-07-10 - Earliest claimed: 2007-10-30 - Assignees: Searete LLC, a limited liability corporation of the State of Delaware - Applicants: SEARETE LLC, A limited liability corporation of the State of Delaware - Inventors: Roderick A. Hyde; Muriel Y. Ishikawa; Lowell L. Wood, JR. - Web page: https://patentgrep.com/patent/US20140194808A1 ## CPC - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants} - A61K 31/095: Sulfur, selenium, or tellurium compounds, e.g. thiols - A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) - A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol - A61K 31/655: Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds - A61K 33/00: Medicinal preparations containing inorganic active ingredients - A61K 41/0042: {Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion} - A61N 5/0601: {Apparatus for use inside the body} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The present disclosure relates to methods and systems for use of photolyzable nitric oxide donors for the treatment of sexual dysfunction. ## Claims ### Claim at position 1 1-50. (canceled) ### Claim 51 A method for treating sexual dysfunction comprising: administering at least one of a lubricant, a gel, a cream, a lotion, or a jelly, that includes a photolyzable nitric oxide donor, to a genital region of an individual; and illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 52 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an internal light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 53 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an implanted light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 54 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an ultraviolet light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 55 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a visible light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 56 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an infrared light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 57 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor, in response to one or more signals. ### Claim 58 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor to treat male erectile dysfunction. ### Claim 59 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor to treat female arousal disorder. ### Claim 60 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an implanted light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor, in response to one or more signals. ### Claim 61 (depends on 51) The method of claim 51, wherein the administering at least one of a lubricant, a gel, a cream, a lotion, or a jelly, that includes a photolyzable nitric oxide donor, to a genital region of an individual comprises: administering at least one of a lubricant, a gel, a cream, a lotion, or a jelly, that includes at least one of the following types of photolyzable nitric oxide donors, to a genital region of an individual: diazeniumdiolate, S-nitrosothiol, organic nitrate, complex of nitric oxide with one or more nucleophiles, L-arginine, molsidomine, CAS754, SPM-5185, SIN-1, nitrosylating compound, or nitroester. ### Claim 62 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using an external light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim at position 14 63-65. (canceled) ### Claim 66 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured for vaginal insertion and that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 67 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured as at least one of a lamp, a flashlight, a wand, a ring, underwear, or a condom and that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 68 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: internally illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 69 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: externally illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 70 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor, in response to activation of a switch associated with the light source. ### Claim 71 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light emitting diode (LED) that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 72 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit, using an optical fiber, light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor. ### Claim 73 (depends on 51) The method of claim 51, wherein the illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor comprises: illuminating the genital region of the individual, using a light source that is configured to emit light that includes a wavelength of light that corresponds to an absorption maximum for the photolyzable nitric oxide donor, to facilitate release of nitric oxide from the photolyzable nitric oxide donor to facilitate achievement of an erection, increase rigidity of an erection, increase blood flow, increase lubrication, increase clitoral vasocongestion, and/or increase duration of an erection. ### Claim at position 23 74-76. (canceled)