# US 2014/0194803 A1 · Wound-healing compositions and method of use

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- Number: US 2014/0194803 A1
- Document ID: US20140194803A1
- Status: Published application
- Kind: A1
- Application number: 14/235,194
- Filed: 2012-07-23
- Published: 2014-07-10
- Earliest claimed: 2011-07-28
- Assignees: Regents of the University of Minnestoa; 3M Innovative Properties Company
- Inventors: Patrick J. Parks; Marnie L. Peterson; Michele J. Anderson
- Web page: https://patentgrep.com/patent/US20140194803A1

## CPC

- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61K 33/42: Phosphorus; Compounds thereof
- A61K 38/2053: {IL-8}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61L 15/44: Medicaments
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 26/0066: {Medicaments; Biocides}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 31/04: Antibacterial agents
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/206: Biguanides, e.g. chlorohexidine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition and wound dressing for treating a skin wound is disclosed. The composition and dressing comprise a pharmaceutically acceptable carrier; an effective amount of an active ingredient of inorganic solids comprising a potassium salt, a zinc salt, a calcium salt, and a rubidium salt; and an antimicrobial biguanide compound comprising an amount effective to reduce the number of viable microorganisms at a wound site. Methods of use include contacting a wound site with the composition and/or dressing.

## Claims

### Claim 1

A composition, comprising:
a pharmaceutically acceptable carrier;
an effective amount of an active ingredient of inorganic solids comprising a potassium salt, a zinc salt, a calcium salt, and a rubidium salt; and
an antimicrobial biguanide compound comprising an amount effective to reduce the number of viable microorganisms at a wound site;
wherein each of the salts comprises a pharmaceutically-acceptable anion.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the active ingredient of inorganic solids comprises 10-80 parts of potassium ions, 0.00001-20 parts of zinc ions, 0.01-10 parts of calcium ions and rubidium ions in an amount up to 40 parts, said parts being expressed as parts by weight of inorganic solids.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the biguanide compound is selected from the group consisting of polyhexamethylene biguanide, chlorhexidine, octenidine, derivatives thereof, and combinations thereof.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the composition comprises about 0.1 weight percent to about 0.5 weight percent of the biguanide compound.

### Claim 5 (depends on 1)

The composition of claim 1 wherein, relative to a composition without the biguanide component, the composition with the biguanide compound suppresses the accumulation of a polypeptide associated with inflammation.

### Claim 6 (depends on 1)

The composition of claim 1 wherein, relative to a composition without the active ingredient, the composition with the active ingredient suppresses the accumulation of a polypeptide associated with inflammation.

### Claim 7 (depends on 5)

The composition of claim 5, wherein the polypeptide associated with inflammation comprises a cytokine

### Claim 8 (depends on 7)

The composition of claim 7, wherein the cytokine comprises interleukin-8.

### Claim 9 (depends on 1)

A wound dressing, comprising:
the composition of claim 1; and
a support.

### Claim 10 (depends on 9)

The wound dressing of claim 9, wherein the support comprises a fibrous material, a film, a gel, a foam, a hydrocolloid, an alginate, a hydrogel a polysaccharide paste, a plurality of granules, a plurality of beads or a combination of any two or more of the foregoing.

### Claim 11 (depends on 9)

The wound dressing of claim 9, further comprising a backing layer.

### Claim 12 (depends on 1)

A method of treating a wound, comprising contacting a wound with the composition of claim 1.

### Claim 13 (depends on 9)

A method of treating a wound, comprising contacting a wound with the wound dressing of claim 9.