# US 2014/0194786 A1 · Method and system for tissue modulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194786 A1 - Document ID: US20140194786A1 - Status: Published application - Kind: A1 - Application number: 14/207,642 - Filed: 2014-03-13 - Published: 2014-07-10 - Earliest claimed: 2009-10-12 - Assignees: Kona Medical, Inc. - Applicants: Kona Medical, Inc. - Inventors: Michael Gertner; David Perozek; Jimin Zhang; Arash Sabet - Web page: https://patentgrep.com/patent/US20140194786A1 ## CPC - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61B 8/44: {Constructional features of the ultrasonic, sonic or infrasonic diagnostic device} - A61B 90/37: {Surgical systems with images on a monitor during operation} - A61N 7/02: Localised ultrasound hyperthermia - A61B 6/506: {for diagnosis of nerves} - A61B 8/4245: {involving determining the position of the probe, e.g. with respect to an external reference frame or to the patient} - A61B 8/485: {involving measuring strain or elastic properties} - A61B 2017/00106: {ultrasonic} - A61B 2018/00404: {Blood vessels other than those in or around the heart} - A61B 2018/00434: {Neural system} - A61B 2018/00511: {Kidney} - A61B 2090/374: {NMR or MRI} - A61N 2007/003: {Destruction of nerve tissue} - A61N 2007/0078: {with multiple treatment transducers} - A61N 2007/0095: {by modifying an excitation signal} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A method of modulating tissue of an internal organ in vivo, includes: fixating the tissue on a shaped device; and focusing radiation on the fixated tissue using a radiation-emitting system so as to modulate the tissue, wherein said radiation-emitting system is non-local with respect to said shaped device. ## Claims ### Claim 1 A method of modulating tissue of an internal organ in vivo, comprising: fixating the tissue on a shaped device; and focusing radiation on the fixated tissue using a radiation-emitting system so as to modulate the tissue, wherein said radiation-emitting system is non-local with respect to said shaped device. ### Claim 2 (depends on 1) The method of claim 1, wherein the focused radiation is focused ultrasound, said shaped device comprises a catheter, and said radiation emitting system is outside of a patient. ### Claim 3 (depends on 1) The method of claim 1, wherein fixating said tissue on said shaped device comprises causing said device to conform to a pre-known size and shape of said tissue. ### Claim 4 (depends on 1) The method of claim 1, wherein fixating said tissue on said shaped device comprises immobilizing said tissue with respect to said device. ### Claim 5 (depends on 1) The method of claim 1, wherein said shaped device comprises a catheter with a balloon. ### Claim 6 (depends on 1) The method of claim 1, wherein said radiation-emitting system is an ionizing radiation emitting system. ### Claim 7 (depends on 1) The method of claim 1, wherein said radiation-emitting system is a noninvasive radiation-emitting system. ### Claim 8 (depends on 1) The method of claim 1, wherein said radiation comprises high intensity focused ultrasound (HIFU). ### Claim 9 (depends on 1) The method of claim 1, further comprising scanning said focused radiation along a pre-determined path. ### Claim 10 (depends on 9) The method of claim 9, further comprising receiving signals indicative of a relative position of said radiation-emitting system with respect to said shaped device, wherein said scanning is responsive to said relative position. ### Claim 11 (depends on 9) The method of claim 9, wherein said scanning comprises moving said radiation-emitting system. ### Claim 12 (depends on 9) The method of claim 9, wherein said scanning is effected by a phased array radiation-emitting system. ### Claim 13 (depends on 1) The method of claim 1, wherein said shaped device comprises a sensor operable to detect and report energy transmitted by said radiation-emitting system. ### Claim 14 (depends on 1) The method of claim 1, wherein said shaped device comprises a reflector operable to reflect energy transmitted by said radiation-emitting system. ### Claim 15 (depends on 1) The method of claim 1, wherein said shaped device comprises an expandable portion sized and shaped to bring elements of said expandable portion into contact with an inner wall of a blood vessel when said expandable portion is expanded within said blood vessel. ### Claim 16 (depends on 15) The method of claim 15, wherein said expandable portion is constrained to a narrow configuration while being advanced through a blood vessel, and is opened into an expanded configuration when positioned at a treatment site. ### Claim 17 (depends on 9) The method of claim 9, further comprising, prior to said modulation of the tissue, operating said radiation-emitting system to emit non-damaging radiation, and correcting said path based on said emission of said non-damaging radiation. ### Claim 18 (depends on 17) The method of claim 17, wherein said radiation to modulate tissue is focused ultrasound, and said non-damaging radiation is diagnostic ultrasound. ### Claim 19 (depends on 1) The method of claim 1, wherein said tissue is nerve tissue. ### Claim 20 (depends on 19) The method of claim 19, wherein said nerve is selected from the group consisting of a nerve leading to a kidney, a sympathetic nerve connected to a kidney, an afferent nerve connected to a kidney, an efferent nerve connected to a kidney, a renal nerve, a renal sympathetic nerve at a renal pedicle, a nerve trunk adjacent to a vertebra, a ganglion adjacent to a vertebra, a dorsal root nerve, an adrenal gland, a nerve next to a kidney, a nerve behind an eye, a celiac plexus, a nerve within a vertebral column, a nerve around a vertebral column, nerve extending to a facet joint and a celiac ganglion. ### Claim 21 (depends on 19) The method of claim 19, wherein said nerve is a renal artery nerve. ### Claim 22 A catheter system, comprising: a) a shaped device adapted for being introduced into a living body and being configured for fixating a tissue thereon so as to shape the tissue generally according to a shape of said device; and b) at least one passive ultrasound sensor mounted on said device and configured for sensing at least one of: a position of said shaped device within a living body, and radiation emitted by an ultrasound radiation-emitting system being external to the body. ### Claim 23 A system for modulating tissue of an internal organ in vivo, comprising: a shaped device adapted for being introduced into a living body and being configured for fixating a tissue thereon so as to shape the tissue generally according to a shape of said device; a radiation-emitting system configured for emitting radiation from a location external to the body and focusing said radiation on the fixated tissue; a scanning system operative to scan said radiation over said fixated tissue; and a controller, configured for controlling said radiation-emitting system and said scanning system such that said scan is along a predetermined path corresponding to said shape of said device so as to from a modulation pattern on the tissue. ### Claim 24 (depends on 23) The system of claim 23, further comprising at least one sensor coupled to said shaped device. ### Claim 25 (depends on 24) The system of claim 24, wherein said at least one sensor comprises a plurality of sensors arranged at a plurality of discrete locations over said shaped device. ### Claim 26 A system for modulating tissue of an internal organ in vivo, comprising: a shaped device adapted for being introduced into a living body; a radiation-emitting system configured for emitting radiation from a location distant from said shaped device and for focusing said radiation on said shaped device; at least one sensor mounted on said device, and being configured for sensing said radiation; and a data processor, configured for analyzing signals received from said at least one sensor and calculate at least one of: a relative location and a distance of a focal region of said radiation.