# US 2014/0194772 A1 · Method and apparatus for measurement of neural response > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194772 A1 - Document ID: US20140194772A1 - Status: Published application - Kind: A1 - Application number: 14/117,153 - Filed: 2012-05-11 - Published: 2014-07-10 - Earliest claimed: 2011-05-13 - Assignees: Saluda Medical Pty Ltd - Inventors: Peter Scott Vallack Single; James Hamilton Laird - Web page: https://patentgrep.com/patent/US20140194772A1 ## CPC - A61B 5/388: Nerve conduction study, e.g. detecting action potential of peripheral nerves - A61B 5/40: {Detecting, measuring or recording for evaluating the nervous system (for sleep A61B5/4806; for anaesthesia A61B5/4821; for pain A61B5/4824)} - A61B 5/4041: {Evaluating nerves condition} - A61N 1/0456: {Specially adapted for transcutaneous electrical nerve stimulation [TENS]} - A61N 1/05: for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) - A61N 1/0551: {Spinal or peripheral nerve electrodes} - A61N 1/36071: {Pain} - A61N 1/36135: {using physiological parameters} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A device for measuring a neural response evoked by a stimulus. First and second sense electrodes are positioned at distinct locations along a neural pathway. A neural stimulus is applied and first and second recordings of a neural response evoked by the stimulus are obtained from the respective sense electrodes. The first recording and the second recording are compared to determine propagation properties of the evoked neural response. ## Claims ### Claim 1 A method of measuring a neural response evoked by a stimulus, the method comprising: applying a neural stimulus; making a first recording of a neural response evoked by the stimulus using a first sense electrode; making a second recording of the neural response evoked by the stimulus using a second sense electrode spaced apart from the first electrode along a neural pathway of the neural response; and comparing the first recording and the second recording to determine propagation properties of the evoked response. ### Claim 2 (depends on 1) The method of claim 1 further comprising comparing the first recording and the second recording in order to gain information regarding a selected neural fibre class. ### Claim 3 (depends on 2) The method of claim 2, where the first and second electrode are a distance d apart and the selected neural fibre class has a conduction velocity of c, the method further comprising delaying the first recording by a time period t=d/c before the comparing. ### Claim 4 (depends on 1) The method of claim 1 wherein the comparing comprises summing together the delayed first recording and the second recording. ### Claim 5 (depends on 1) The method of claim 1 wherein the comparing comprises cross-correlating the delayed first recording with the second recording. ### Claim 6 (depends on 1) The method of claim 1, wherein more than two recordings are obtained from respective electrodes spaced apart along the neural pathway, ### Claim 7 (depends on 1) The method of claim 1 wherein the comparison is performed for variable delays ti, to yield a propagram reflecting the comparison outcome with respect to ti. ### Claim 8 (depends on 7) The method of claim 7 further comprising using the amplitude of a peak in the propagram as feedback to control a stimulus to provide desired selectivity of recruitment of a fibre class associated with the peak. ### Claim 9 (depends on 1) The method of claim 1 wherein gain values are applied to each recording prior to the comparing, to compensate for neural response signal attenuation along the neural pathway. ### Claim 10 (depends on 1) The method of claim 1 wherein phase terms are applied to each recording prior to the comparing, to compensate for dispersion of the neural signal along the neural pathway. ### Claim 11 (depends on 1) The method of claim 1 further comprising applying a filter to each recording prior to the comparing, the filter being matched to an expected response. ### Claim 12 (depends on 1) The method of claim 1 wherein one sense electrode is positioned caudally of the stimulus site, and another sense electrode is positioned rostrally of the stimulus site. ### Claim 13 A device for measuring a neural response evoked by a stimulus, the device comprising: at least first and second sense electrodes which are configured to be positioned at distinct locations along a neural pathway; and a control unit configured to apply a neural stimulus, the control unit further configured to make a first recording of a neural response evoked by the stimulus using a first sense electrode, the control unit further configured to make a second recording of the neural response evoked by the stimulus using the second sense electrode; and the control unit further configured to compare the first recording and the second recording to determine propagation properties of the evoked neural response.