# US 2014/0194736 A1 · Method, apparatus and computer accessible medium for providing signal and contrast enhancement(s) in optical imaging methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194736 A1 - Document ID: US20140194736A1 - Status: Published application - Kind: A1 - Application number: 14/147,403 - Filed: 2014-01-03 - Published: 2014-07-10 - Earliest claimed: 2013-01-04 - Assignees: The General Hospital Corporation - Inventors: Guillermo J. Tearney; Tao Wu; Dongkyun Kang; Melissa J. Suter - Web page: https://patentgrep.com/patent/US20140194736A1 ## CPC - A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)} - A61B 1/041: {Capsule endoscopes for imaging} - A61B 1/043: {for fluorescence imaging} - A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)} - A61B 5/0062: {Arrangements for scanning} - A61B 5/0066: {Optical coherence imaging} - A61B 5/0071: {by measuring fluorescence emission} - A61B 5/0073: {by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence)} - A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)} - A61B 5/6852: {Catheters} - A61B 5/6861: {Capsules, e.g. for swallowing or implanting} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system for facilitating imaging of an anatomical structure(s) can be provided, and can include, for example, a substance which can induce a change in the anatomical structure(s) when applied to the anatomical structure(s), and an imaging arrangement which can be configured to generate an image of the anatomical structure(s) based on the change of the anatomical structure(s) when the substance is applied. The imaging arrangement can include an apparatus which can be configured to (i) illuminate the anatomical structure(s) with a first electro-magnetic radiation(s), and (ii) receive a second electro-magnetic radiation from the anatomical structure(s) that can be based on the first electro-magnetic radiation. The change can affect a characteristic(s) of the second electro-magnetic radiation. ## Claims ### Claim 1 A system for facilitating imaging of at least one anatomical structure, comprising: a substance which induces a change in the at least one anatomical structure when applied; and an imaging arrangement which is configured to generate an image of the at least one anatomical structure based on the change of the at least one anatomical structure when the substance is applied. ### Claim 2 (depends on 1) The system according to claim 1, wherein the imaging arrangement further comprising an apparatus which is configured to (i) illuminate the at least one anatomical structure with a first electro-magnetic radiation(s), and (ii) receive a second electro-magnetic radiation from the at least one anatomical structure that is based on the first electro-magnetic radiation, and wherein the change effects at least one characteristic of the second electro-magnetic radiation. ### Claim 3 (depends on 2) The system according to claim 2, wherein the change is at least one of linear or nonlinear optical processes, including a reflectance, fluorescence, Raman scattering, and harmonic generation, or sum/difference frequency generation of the first electro-magnetic radiation(s) to become the second electro-magnetic radiation. ### Claim 4 (depends on 1) The system according to claim 1, wherein the imaging arrangement is a microscopic imaging arrangement. ### Claim 5 (depends on 4) The system according to claim 4, wherein the microscopic imaging arrangement operates based on at least one of confocal microscopy (SECM), optical coherence tomography ( ) second or higher order harmonic microscopy, sum/difference frequency fluorescence microscopy, or Raman microscopy (including at least one of CARS or SRS). ### Claim 6 (depends on 5) The system according to claim 5, wherein the optical coherenece tomography includes at least one of optical frequency domain interferometry (OFDI), spectral docmain optical coherence tomography (SD-OCT) or Full-field optical coherence microscopy (FFOCM). ### Claim 7 (depends on 1) The system according to claim 1, wherein the imaging arrangement has a structure that is configured to be delivered into the at least one anatomical structure. ### Claim 8 (depends on 1) The system according to claim 1, wherein the imaging arrangement has a shape of a pill and is delivered to the at least one anatomical structure. ### Claim 9 (depends on 8) The system according to claim 8, wherein a length of the pill is less than 35 mm, and a width of the pill is less than 15 mm. ### Claim 10 (depends on 8) The system according to claim 8, wherein the imaging arrangement includes a tether that is connected to the pill. ### Claim 11 (depends on 1) The system according to claim 1, wherein the imaging arrangement comprises a housing which is coated by the substance. ### Claim 12 (depends on 1) The system according to claim 1, wherein the substance includes at least one of acetic acid, tartaric acid, citric acid, malic acid, adipic acid, succinic acid, fumaric acid, hydrochloric acid, cocktail mix, or a further acidic solution which pH value is lower than 5.0. ### Claim 13 (depends on 1) The system according to claim 1, wherein the substance includes at least one of lemon juice, lime juice, orange juice, vinegar, fruit vinegar, or a further acidic juice which pH value is lower than 5.0. ### Claim 14 (depends on 1) The system according to claim 1, wherein the substance is a sour candy. ### Claim 15 (depends on 1) The system according to claim 1, wherein the substance contains miraculin. ### Claim 16 (depends on 1) The system according to claim 1, further comprising a further ingestible substance (i) which is ingested prior to the ingestion of the substance, and (ii) which alters the taste of the substance. ### Claim 17 (depends on 1) The system according to claim 1, further comprising a further ingestible substance which has a viscosity which is higher than that of water, wherein the substance and the further substance are mixed prior to ingestion. ### Claim 18 (depends on 14) The system according to claim 14, wherein the further ingestible substance includes maple syrup, corn syrup, or sugar syrup. ### Claim 19 (depends on 14) The system according to claim 14, wherein the further ingestible substance includes at least one of sugar, glucose, sucrose, fructose, sucralose, lactose, galactose, maltose, maltodextrin, corn starch, or guar gum. ### Claim 20 A system for facilitating imaging of at least one anatomical structure, comprising: a first arrangement which holds a substance therein and is configured to apply the substance to the at least one anatomical structure, wherein, upon application by the first arrangement on the at least one anatomical structure, the substance induces a change in the at least one anatomical structure; and a second arrangement which is configured generate an image of the at least one anatomical structure based on the change of the at least one anatomical structure when the substance is applied to the at least one anatomical structure by the first arrangement, wherein at least one of the first or second arrangements are provided in a housing that has a shape of a pill, and configured to be swallowed. ### Claim 21 (depends on 20) The system according to claim 20, wherein the first and second arrangements are situated in the housing.