# US 2014/0194728 A1 · Real time control of high intensity focused ultrasound using magnetic resonance imaging > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194728 A1 - Document ID: US20140194728A1 - Status: Published application - Kind: A1 - Application number: 14/239,268 - Filed: 2012-08-27 - Published: 2014-07-10 - Earliest claimed: 2011-08-30 - Assignees: Koninklijke Philips N.V. - Inventors: Erkki Tapani Vahala - Web page: https://patentgrep.com/patent/US20140194728A1 ## CPC - G01R 33/285: {Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR} - A61B 5/0036: {including treatment, e.g., using an implantable medical device, ablating, ventilating} - A61B 8/485: {involving measuring strain or elastic properties} - A61B 17/320016: {Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes (A61B10/0233, A61B17/29, A61B17/3207 take precedence)} - A61N 7/02: Localised ultrasound hyperthermia - G01R 33/4814: {MR combined with ultrasound} - G01R 33/4818: {MR characterised by data acquisition along a specific k-space trajectory or by the temporal order of k-space coverage, e.g. centric or segmented coverage of k-space} - A61B 8/565: {involving data transmission via a network} - A61B 2017/320069: {for ablating tissue} - A61B 2090/374: {NMR or MRI} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A medical apparatus (300, 400, 500) comprises a high intensity focused ultrasound system (322) configured for for sonicating a target volume (340) of a subject (318). The medical apparatus further comprises a magnetic resonance imaging system (302) for acquiring magnetic resonance data (356, 358, 360, 368, 374) from an imaging zone (308). The treatment volume is within the imaging zone. The medical apparatus further comprises a memory (352) containing machine executable,a control module (382, 402) for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, and a processor (346). Execution of the instructions causes the processor to repeatedly acquire (102, 202) magnetic resonance data in real time using the magnetic resonance imaging system and control (104, 206) sonication of the target volume by the high intensity focused ultra-sound system in real time using the sonication control module and the magnetic resonance data. ## Claims ### Claim 1 A medical apparatus comprising: a high intensity focused ultrasound system configured for generating focused ultrasonic energy for sonicating a target volume of a subject; a magnetic resonance imaging system for acquiring magnetic resonance data from an imaging zone, wherein the treatment volume is within the imaging zone; a memory containing machine executable instructions for controlling the medical apparatus; a control module for controlling the sonication of the target volume using the magnetic resonance data as a control parameter; a processor for controlling the medical apparatus, wherein execution of the instructions causes the processor to repeatedly: acquire magnetic resonance data in real time using the magnetic resonance imaging system; and control sonication of the target volume by the high intensity focused ultrasound system in real time using the sonication control module and the magnetic resonance data and wherein the magnetic resonance data comprises subsampled magnetic resonance data (358) and image magnetic resonance data, wherein the medical apparatus further comprises an image reconstruction module for reconstructing the image magnetic resonance data into a magnetic resonance image, where the sonication control module is configured for using at least the subsampled magnetic resonance data as the control parameter, and wherein execution of the instructions further causes the processor to repeatedly reconstruct an image using the image reconstruction module and the image magnetic resonance data and the magnetic resonance imaging system acquires the subsampled magnetic resonance data and image magnetic resonance data in an interleaved fashion. ### Claim at position 2 2-3. (canceled) ### Claim 4 (depends on 1) The medical apparatus of claim 1, wherein the subsampled magnetic resonance data is subsampled in comparison to the image magnetic resonance data. ### Claim 5 (depends on 4) The medical apparatus of claim 4, the subsampled magnetic resonance data is subsampled by under sampling in k-space. ### Claim 6 (depends on 5) The medical apparatus of claim 5, wherein the under sampling of k-space of is non-uniformly distributed in k-space. ### Claim 7 (depends on 5) The medical apparatus of claim 5, wherein under sampling of the k-space is performed using any one of the following: a predetermined sampling pattern, a random sampling pattern, by sampling k-space elements determined by a Poisson-disk distribution, by sampling k-space within a predetermined region of k-space, and by sampling fully a kernel of k-space below a predetermined value of k and sparsely sampling above the predetermined value of k. ### Claim 8 (depends on 1) The medical apparatus of claim 1, wherein the subsampled magnetic resonance data comprises magnetic resonance navigator data. ### Claim 9 (depends on 1) The medical apparatus of claim 1, wherein the medical imaging system further comprises an elastrographic ultrasound system, wherein the instructions further cause the processor to activate the elastrographic ultrasound system when acquiring at least a portion of the magnetic resonance data, wherein the sonication control module is configured to use at least the portion of the magnetic resonance data acquired when the elastrographic ultrasound system was active for controlling the sonication. ### Claim 10 (depends on 1) The medical apparatus of claim 1, wherein execution of the instructions further causes the controller to repeatedly calculate an energy deposition map using the magnetic resonance data, wherein the sonication control module is configured to determine sonication trajectories and timing values in accordance with the energy deposition map. ### Claim 11 (depends on 1) The medical apparatus of claim 1, wherein execution of the instructions causes the processor to broadcast the magnetic resonance data to the sonication control module. ### Claim 12 (depends on 1) The medical apparatus of claim 1, wherein the sonication control module is configured to control the high intensity focused ultrasound system without generating images from the magnetic resonance data. ### Claim 13 A method of operating a medical apparatus, wherein the medical apparatus comprises a high intensity focused ultrasound system configured for generating focused ultrasonic energy for sonicating a target volume of a subject, wherein the medical apparatus further comprises a magnetic resonance imaging system for acquiring magnetic resonance data from an imaging zone, wherein the treatment volume is within the imaging zone, wherein the medical apparatus further comprises a control module for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, wherein the method comprises the steps of repeatedly: acquiring magnetic resonance data in real time using the magnetic resonance imaging system; and controlling sonication of the target volume by the high intensity focused ultrasound system in real time using the sonication control module and the magnetic resonance data and wherein the magnetic resonance data comprises subsampled magnetic resonance data and image magnetic resonance data are acquired in an interleaved fashion by the magnetic resonance imaging system, reconstructing an image reconstruction module by way of the image magnetic resonance data into a magnetic resonance image, using at least the subsampled magnetic resonance data as the control parameter by the sonication control module, repeatedly reconstructing by the processor an image using the image reconstruction module and the image magnetic resonance data. ### Claim 14 A computer program product comprising machine executable instructions for execution by a processor controlling a medical apparatus, wherein the medical apparatus comprises a high intensity focused ultrasound system configured for generating focused ultrasonic energy for sonicating a target volume of a subject, wherein the medical apparatus further comprises a magnetic resonance imaging system for acquiring magnetic resonance data from an imaging zone, wherein the medical apparatus further comprises a control module for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, wherein execution of the instructions causes the processor to repeatedly: acquire magnetic resonance data in real time using the magnetic resonance imaging system; and control sonication of the target volume by the high intensity focused ultrasound system in real time using the sonication control module and the magnetic resonance data and acquire the magnetic resonance data comprising subsampled magnetic resonance data and image magnetic resonance data are in an interleaved fashion by the magnetic resonance imaging system, reconstruct an image reconstruction module by way of the image magnetic resonance data into a magnetic resonance image, use at least the subsampled magnetic resonance data as the control parameter by the sonication control module, repeatedly reconstruct by the processor an image using the image reconstruction module and the image magnetic resonance data.