# US 2014/0194725 A1 · Brain disease diagnosis system

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- Number: US 2014/0194725 A1
- Document ID: US20140194725A1
- Status: Published application
- Kind: A1
- Application number: 14/208,479
- Filed: 2014-03-13
- Published: 2014-07-10
- Earliest claimed: 2008-07-07
- Assignees: Hamamatsu Photonics K.K.
- Applicants: Hamamatsu Photonics K.K.
- Inventors: Akihiro KAKIMOTO; Yoshiyuki SHIMIZU; Tsuyoshi KOSUGI; Hiroyuki OKADA
- Web page: https://patentgrep.com/patent/US20140194725A1

## CPC

- A61B 5/0042: {for the brain}
- A61B 5/4088: {Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia}
- G06T 7/0012: {Biomedical image inspection}
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16Z 99/00: Subject matter not provided for in other main groups of this subclass
- A61B 6/03: Computed tomography [CT]
- G06T 2207/10072: Tomographic images
- G06T 2207/30016: Brain
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16Z: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR

## Abstract

An object of the present invention is to perform a more accurate and detailed diagnosis of a brain disease. A diagnosis server 10 of the brain disease diagnosis system 1 for diagnosing a brain disease of an examined person includes: an acquiring unit 11 for acquiring a brain image of the examined person so as to obtain an acquired image; a region setting unit 12 for setting a plurality of regions in the acquired image; an individual index value calculating unit 13 for calculating an individual index value based on a pixel value of the acquired image, in each of the plurality of regions; a whole index value calculating unit 14 for calculating a whole index value by weighting the individual index value of each of the plurality of regions; a diagnosis unit 15 for diagnosing the brain disease of the examined person based on the whole index value; and an output unit 16 for outputting information indicating a diagnosis outcome.

## Claims

### Claim 1

A brain disease diagnosis system for diagnosing a brain disease of an examined person, comprising:
acquiring means for acquiring a brain image of the examined person so as to obtain an acquired image;
region setting means for setting a plurality of regions in the acquired image acquired by the acquiring means;
individual index value calculating means for calculating an individual index value based on a pixel value of the acquired image, in each of the plurality of regions set by the region setting means;
whole index value calculating means for calculating a whole index value by weighting the individual index value of each of the plurality of regions calculated by the individual index value calculating means;
diagnosis means for diagnosing the brain disease of the examined person based on the whole index value calculated by the whole index value calculating means; and
output means for outputting information indicating a diagnosis outcome issued by the diagnosis means.

### Claim 2 (depends on 1)

The brain disease diagnosis system according to claim 1, wherein the diagnosis means diagnoses the brain disease of the examined person by comparing a threshold value obtained based on an index value of sample data having the brain disease and an index value of sample data not having the brain disease and the whole index value calculated by the whole index value calculating means.

### Claim 3 (depends on 1)

The brain disease diagnosis system according to claim 1, wherein the whole index value calculating means performs the weighting based on the index value of the sample data having the brain disease and the index value of the sample data not having the brain disease.

### Claim 4 (depends on 1)

The brain disease diagnosis system according to claim 1, wherein the acquiring means corrects the image based on the pixel value of the acquired brain image so as to obtain the acquired image.

### Claim 5 (depends on 1)

The brain disease diagnosis system according to claim 1, wherein
the acquiring means also acquires information indicating the age of the examined person, and
the diagnosis means diagnoses the brain disease of the examined person according to the age of the examined person indicated by the information acquired by the acquiring means.

### Claim 6 (depends on 1)

The brain disease diagnosis system according to claim 1, wherein the acquiring means anatomically standardizes the acquired brain image so as to obtain the acquired image.

### Claim 7 (depends on 1)

The brain disease diagnosis system according to claim 1, further comprising imaging means for imaging the brain image of the examined person, wherein
the acquiring means acquires the image imaged by the imaging means.

### Claim 8 (depends on 7)

The brain disease diagnosis system according to claim 7, wherein
the imaging means images a slice image of a brain of the examined person as the brain image of the examined person, and
the acquiring means produces from the slice image imaged by the imaging means a brain surface projection image obtained by projecting a brain surface of the brain so as to obtain the acquired image.