# US 2014/0194714 A1 · Electrophysiological analysis system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194714 A1 - Document ID: US20140194714A1 - Status: Published application - Kind: A1 - Application number: 14/173,317 - Filed: 2014-02-05 - Published: 2014-07-10 - Earliest claimed: 2007-02-23 - Assignees: Impeto Medical - Applicants: Impeto Medical - Inventors: Philippe Brunswick; Nicolas Bocquet - Web page: https://patentgrep.com/patent/US20140194714A1 ## CPC - A61B 5/1477: non-invasive - A61B 5/05: Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24) - A61B 5/053: Measuring electrical impedance or conductance of a portion of the body - A61B 5/14539: {for measuring pH} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/1495: Calibrating or testing of in-vivo probes - A61B 5/6825: {Hand} - A61B 5/6829: {Foot or ankle} - A61B 5/7282: {Event detection, e.g. detecting unique waveforms indicative of a medical condition (cough events A61B5/0823; seizures A61B5/4094; sleep apnoea A61B5/4818)} - A61B 5/743: {Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The invention provides an electrophysiological analysis system, in particular for detecting pathological states. This system comprises: electrodes intended to be placed in different regions of the body that are well away from each other; an adjustable DC voltage source for generating successive DC voltage pulses varying in magnitude from one pulse to another, the duration of the pulses being equal to or greater than about 0.2 seconds; a switching circuit for selectively connecting a pair of active electrodes to the voltage source and for connecting at least one other high-impedance electrode; and a measurement circuit for recording data representative of the current in the active electrodes and potentials on at least certain high-impedance connected electrodes in response to the application of said pulses. The range of voltages covered causes, from one pulse to another, the appearance or disappearance of electrochemical phenomena in the vicinity of the active electrodes. ## Claims ### Claim 1 An electrophysiological analysis system for use on a patient, the system comprising: (a) a right hand-electrode including a rigid metallic surface capable of contracting an entire extent of a right hand of the patient; (b) a left hand-electrode including a rigid metallic surface capable of contacting an entire extent of a left hand of the patient; (c) at least one foot-electrode including a rigid metallic surface capable of contacting an entire extent of at least one foot of the patient; (d) a computer coupled to the electrodes; (e) data corresponding to weight of the patient being entered into the computer; (f) data corresponding to age of the patient being entered into the computer; (g) the computer operably sending signals to an electronic circuit to provide voltage to at least one of the electrodes capable of causing an electrochemical phenomena in an adjacent portion of the patient; (h) the computer operably measuring values from the electrodes associated with the electrochemical phenomena associated therewith; (i) the computer operably comparing the measured values with pre-stored reference data associated with the patient weight and age data; and (j) a display screen coupled to the computer operably displaying information indicative of a medical condition of the patient based on the computer comparison. ### Claim 2 (depends on 1) The system of claim 1, wherein the computer displays diagnostic measurement data related to the electrochemical phenomena of the patient on the display screen by detecting variations in pH at at least one of the electrodes. ### Claim 3 (depends on 2) The system of claim 2, wherein the computer assists in diagnosing cystic fibrosis. ### Claim 4 (depends on 2) The system of claim 2, wherein the computer assists in diagnosing acidosis and alkalosis disorders of the patient, based at least in part on voltage. ### Claim 5 (depends on 2) The system of claim 2, wherein the computer assists in diagnosing vascular dysfunctions, based at least in part on voltage. ### Claim 6 (depends on 2) The system of claim 2, wherein the computer assists in diagnosing hormonal dysfunctions, based at least in part on voltage. ### Claim 7 (depends on 2) The system of claim 2, wherein the computer assists in diagnosing at least one of: diabetes, neuropathy disease, or renal failure, based at least in part on voltage. ### Claim 8 (depends on 1) The system of claim 1, wherein all of the electrodes are of the same material. ### Claim 9 (depends on 1) The system of claim 1, wherein the electrodes operably carry out electrochemical measurements involving chlorides. ### Claim 10 (depends on 1) The system of claim 1, wherein the computer causes polarity reversal of the right and left electrodes. ### Claim 11 (depends on 1) The system of claim 1, further comprising a variable measurement resistor electrically connected between at least one of the electrodes and a reference voltage, being adjustable to optimize a voltage measurement in relation to an observed current level. ### Claim 12 An electrophysiological analysis system for use on a patient, the system comprising: (a) a rigid right hand-electrode; (b) a rigid left hand-electrode; (c) a rigid right foot-electrode; (d) a rigid left foot-electrode; (e) a computer coupled to the electrodes, patient age or weight data being input into the computer; (f) a direct current voltage source controlled by the computer, the computer causing polarity to switch between the electrodes; (g) the computer using analogue-to-digital conversion to assist with measurements from the electrodes; and (h) a resistor electrically connected to at least one of the electrodes. ### Claim 13 (depends on 12) The system of claim 12, wherein the hand electrodes are each sized to be in contact with a patient's hand over substantially the entire extent thereof. ### Claim 14 (depends on 12) The system of claim 12, wherein the foot electrodes are each sized to be in contact with a patient's foot over substantially the entire extent thereof. ### Claim 15 (depends on 12) The system of claim 12, wherein all of the electrodes are of the same material and the electrodes operably carry out electrochemical measurements involving chlorides. ### Claim 16 (depends on 12) The system of claim 12, wherein the computer causes polarity reversal of the right and left electrodes. ### Claim 17 (depends on 12) The system of claim 12, further comprising diagnostic measurement data, related to electrochemical phenomena of the patient detected via variations in pH at the electrodes, is displayed on a display screen coupled to the computer. ### Claim 18 (depends on 12) The system of claim 12, wherein the computer assists in diagnosing cystic fibrosis. ### Claim 19 (depends on 12) The system of claim 12, wherein the computer assists in diagnosing diabetes by displaying data in a radar curve on a display screen. ### Claim 20 (depends on 12) The system of claim 12, wherein the computer compares data detected by the electrodes in real-time with stored data previously obtained from the same patient for monitoring the effect of a diabetes treatment. ### Claim 21 (depends on 12) The system of claim 12, wherein the computer compares data detected by the electrodes in real-time with stored data previously obtained from the same patient for monitoring the effect of a cystic fibrosis treatment. ### Claim 22 An electrophysiological analysis system for use on a patient, the system comprising: (a) a rigid right hand-electrode; (b) a rigid left hand-electrode; (c) a rigid right foot-electrode; (d) a rigid left foot-electrode; (e) a computer coupled to the electrodes which operably carry out electrochemical measurements involving chlorides of the patient; (f) a display screen coupled to the computer; and (g) a direct current voltage source coupled to the computer, and the computer causing polarity to switch between the electrodes; (h) the computer comparing data detected by the electrodes in real-time with stored data previously obtained from the same patient for monitoring the effect of a cystic fibrosis treatment. ### Claim 23 (depends on 22) The system of claim 22, wherein the hand electrodes are each sized to be in contact with a hand of the patient over the entire extent thereof. ### Claim 24 (depends on 23) The system of claim 23, wherein the foot electrodes are each sized to be in contact with a foot of the patient over the entire extent thereof. ### Claim 25 (depends on 22) The system of claim 22, wherein all of the electrodes are of the same material, and the electrodes are suitable for carrying out electrochemical measurements involving pH of the patient. ### Claim 26 (depends on 22) The system of claim 22, wherein the computer causes polarity reversal of the right and left electrodes, further comprising diagnostic measurement data, related to electrochemical phenomena of the patient detected via variations in pH at the electrodes, is displayed on the display screen. ### Claim 27 (depends on 22) The system of claim 22, wherein the computer compares the data detected by the electrodes in real-time with stored reference data previously obtained from reference healthy and reference cystic fibrosis patients, and visually displays a graph of the compared data. ### Claim 28 An electrophysiological analysis system for use on a patient, the system comprising: (a) a right hand-electrode having a metallic surface sized to contact with skin over the entire extent of a hand of the patient; (b) a left hand-electrode having a metallic surface sized to contact with skin over the entire extent of a hand of the patient; (c) a right foot-electrode having a metallic surface sized to contact with skin over the entire extent of a foot of the patient; (d) a rigid left foot-electrode having a metallic surface sized to contact with skin over the entire extent of a foot of the patient; (e) a computer coupled to the electrodes; and (f) a direct current voltage source coupled to the computer, and the computer causing polarity to switch between the electrodes; (g) the electrodes operably sending signals to the computer responsive to at least one of: electrochemical measurements involving chlorides or pH, of the patient adjacent the electrodes; and (h) the computer comparing data detected by the electrodes in real-time from the patient with stored data previously obtained to assist in detection of at least one patient illness comprising: (i) cystic fibrosis, or (ii) diabetes. ### Claim 29 (depends on 28) The system of claim 28, wherein the computer causes the polarity reversal of the right and left electrodes, further comprising diagnostic measurement data, related to electrochemical phenomena of the patient detected via variations in pH at the electrodes, displayed on a display screen and the computer comparing the real-time data with the stored reference data previously obtained from reference healthy and reference cystic fibrosis patients, and visually displaying a graph of the compared data. ### Claim 30 (depends on 28) The system of claim 28, wherein all of the electrodes are of the same material, and the electrodes are suitable for carrying out electrochemical measurements involving pH of the patient.