# US 2014/0194713 A1 · Contact lenses having two-electrode electrochemical sensors

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- Number: US 2014/0194713 A1
- Document ID: US20140194713A1
- Status: Published application
- Kind: A1
- Application number: 14/029,281
- Filed: 2013-09-17
- Published: 2014-07-10
- Earliest claimed: 2012-08-06
- Assignees: Google Inc.
- Applicants: Google Inc.
- Inventors: Zenghe Liu
- Web page: https://patentgrep.com/patent/US20140194713A1

## CPC

- A61B 5/1486: using enzyme electrodes, e.g. with immobilised oxidase
- A61B 5/0004: {characterised by the type of physiological signal transmitted}
- A61B 5/14507: {specially adapted for measuring characteristics of body fluids other than blood (devices for taking samples of body liquids A61B10/0045)}
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/6821: {Eye}
- A61B 5/002: {Monitoring the patient using a local or closed circuit, e.g. in a room or building (A61B5/0017 takes precedence)}
- A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
- A61B 5/1495: Calibrating or testing of in-vivo probes
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

## Claims

### Claim 1

A contact lens, comprising:
a substrate that forms at least part of a body of the contact lens; and
a circuit, disposed on or within the substrate, wherein the circuit comprises a communication component and a two-electrode electrochemical sensor, wherein the communication component comprises an antenna, and wherein the two-electrode electrochemical sensor comprises:
a working electrode; and
a combination reference-counter electrode.

### Claim 2 (depends on 1)

The contact lens of claim 1, wherein the working electrode generates a signal indicative of a sensed analyte.

### Claim 3 (depends on 2)

The contact lens of claim 2, wherein the combination reference-counter electrode passes the signal generated from the working electrode.

### Claim 4 (depends on 1)

The contact lens of claim 1, wherein the working electrode and the combination reference-counter electrode are comprised of a same material.

### Claim 5 (depends on 1)

The contact lens of claim 1, wherein the working electrode is comprised of platinum and the combination reference-counter electrode is comprised of a noble metal.

### Claim 6 (depends on 1)

The contact lens of claim 1, wherein the combination reference-counter electrode is comprised of at least one of carbon or silver/silver chloride.

### Claim 7 (depends on 1)

The contact lens of claim 1, wherein the two-electrode electrochemical sensor comprises a hydrogen peroxide sensor with two platinum electrodes.

### Claim 8 (depends on 1)

The contact lens of claim 1, wherein the two-electrode electrochemical sensor is an amperometric sensor.

### Claim 9 (depends on 8)

The contact lens of claim 8, wherein the amperometric sensor is a biosensor that senses a level of at least one of glucose, protein, triglycerides, urea or lactate in a body of a wearer of the contact lens.

### Claim 10 (depends on 8)

The contact lens of claim 8, wherein the amperometric sensor comprises a working electrode having glucose oxidase deposited on the working electrode.

### Claim 11 (depends on 1)

The contact lens of claim 1, wherein the working electrode is smaller than the combination reference-counter electrode.

### Claim 12 (depends on 11)

The contact lens of claim 11, wherein a ratio of an area of the combination reference-counter electrode and an area of the working electrode is between 2 and 10000.

### Claim at position 13

13-20. (canceled)