# US 2014/0194701 A1 · Gateway platform for biological monitoring and delivery of therapeutic compounds

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- Number: US 2014/0194701 A1
- Document ID: US20140194701A1
- Status: Published application
- Kind: A1
- Application number: 14/159,429
- Filed: 2014-01-20
- Published: 2014-07-10
- Earliest claimed: 2006-04-25
- Applicants: PhiloMetron, Inc.
- Inventors: Darrel DRINAN; Carl EDMAN; Diethard MERZ
- Web page: https://patentgrep.com/patent/US20140194701A1

## CPC

- G16H 20/13: delivered from dispensers
- A61B 5/0002: {Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network (endoradiosondes A61B5/07)}
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B 5/14539: {for measuring pH}
- A61B 5/24: Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B 5/411: {Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance}
- A61B 5/4839: {combined with drug delivery}
- A61B 5/486: {Biofeedback (using electroencephalography [EEG] A61B5/375)}
- G16H 40/63: for local operation
- G16H 40/67: for remote operation
- A61B 5/02: Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B 5/08: Measuring devices for evaluating the respiratory organs
- A61B 5/082: {Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath (A61B5/083, A61B5/091 take precedence)}
- A61B 5/145: Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value {; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue} (non-radiation detecting or locating of foreign bodies in blood A61B5/06)
- A61B 2560/0271: using a remote monitoring unit
- A61M 5/14276: {specially adapted for implantation}
- A61M 2005/1726: {the body parameters being measured at, or proximate to, the infusion site}
- A61M 2205/3523: using telemetric means
- A61M 2205/3569: sublocal, e.g. between console and disposable
- G16H 10/60: for patient-specific data, e.g. for electronic patient records
- Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
- Y10S 128/903: Radio telemetry
- Y10S 128/904: Telephone telemetry
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party. The device provides for a universal platform for sensors, and further provides for the automatic compensation or distribution of devices or bioactive agents at appropriate levels and/or intervals in response to deviations or other states sensed in various physiological parameters.

## Claims

### Claim 1

A system for monitoring physiological status of a mammalian subject, comprising:
at least one biointerface head (BIH), said at least one BIH being attached to an external surface of said subject and configured to communicate data and a BIH identifier;
at least one control and communication module (CCM) storing a CCM identifier and which is linked to at least one biointerface head to receive said data and said BIH identifier, wherein said control and communication module receives data from at least one biointerface head;
at least one data collection unit (DCU) which receives data and said identifiers from the control and communication module; and
a remote database management system which receives data from at least one data collection unit and processes said data.

### Claim 2 (depends on 1)

The system of claim 1, wherein said BIH comprises a device for therapeutic compound delivery.

### Claim 3 (depends on 1)

The system of claim 1, wherein said BIH comprises a physiological parameter sensor.

### Claim 4 (depends on 1)

The system of claim 1, wherein said biointerface head is attached to said mammalian subject with at least one adhesive.

### Claim 5 (depends on 1)

The system of claim 1, wherein said control and communication module is attached to said mammalian subject with at least one adhesive.

### Claim 6 (depends on 1)

The system of claim 1, wherein said system comprises a transdermal conduit and a biofluid access port, and wherein the transdermal conduit and biofluid access port are coated with a hydrogel material.

### Claim 7 (depends on 1)

The system of claim 1, wherein said system further comprises a chamber which releases one or more therapeutic agents.

### Claim 8 (depends on 1)

The system of claim 1, wherein said data collection unit processes information before sending information to said remote data management system.

### Claim 9 (depends on 1)

The system of claim 1, wherein the data management system provides feedback to the data collection unit and/or the communication module.

### Claim 10 (depends on 1)

The system of claim 1, wherein said feedback comprises diagnostic knowledge.

### Claim 11 (depends on 1)

The system of claim 1, wherein said feedback comprises actions and/or instructions.

### Claim 12 (depends on 1)

The system of claim 1, comprising a plurality of communication modules.

### Claim 13 (depends on 1)

The system of claim 1, comprising a plurality of data collection units.

### Claim 14 (depends on 1)

The system of claim 1, wherein data is transmitted from a BIH, through a plurality of CCMs, to a DCU.

### Claim at position 15

15-27. (canceled)