# US 2014/0194621 A1 · Process for producing benzo [b] [1,4] diazepine-2, 4-dione compound

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- Number: US 2014/0194621 A1
- Document ID: US20140194621A1
- Status: Published application
- Kind: A1
- Application number: 14/202,793
- Filed: 2014-03-10
- Published: 2014-07-10
- Earliest claimed: 2009-08-21
- Assignees: Otsuka Pharmaceutical Co., Ltd.
- Applicants: Otsuka Pharmaceutical Co., Ltd.
- Inventors: Hisayuki TSUJIMORI; Shinichi TAIRA; Hirotaka YUKAWA; Kaoru ABE
- Web page: https://patentgrep.com/patent/US20140194621A1

## CPC

- C07D 243/12: 1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A61P 9/06: Antiarrhythmics
- C07D 243/14: 1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- Y02P 20/55: Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

A process for producing a compound represented by formula (1), wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process includes deprotecting a protective group (R5) of a compound represented by formula (2), wherein R1, R2, R3 and R4 are as defined above, and R5 represents a protective group of a hydroxy group. The process is an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia.

## Claims

### Claim 1

A compound represented by formula (2),
wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, and R5 represents a protective group of a hydroxy group.

### Claim 2

A compound represented by formula (2A),
wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, and R5 represents a protective group of a hydroxy group.

### Claim 3 (depends on 1)

The compound according to claim 1, which is represented by formula (2a),
wherein each of R1A, R2A and R3A, which may be the same or different, represents a lower alkyl group, and R4 and R5 are as defined above.