# US 2014/0194533 A1 · Biocompatible and biodegradable elastomer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194533 A1 - Document ID: US20140194533A1 - Status: Published application - Kind: A1 - Application number: 14/145,393 - Filed: 2013-12-31 - Published: 2014-07-10 - Earliest claimed: 2013-01-02 - Assignees: National Taiwan University - Applicants: National Taiwan University - Inventors: Shan-hui Hsu; Kun-Che Hung; Shenghong A. Dai; Chun-Yi Lu - Web page: https://patentgrep.com/patent/US20140194533A1 ## CPC - A61F 2/06: Blood vessels - A61L 27/165: {Rubbers} - A61L 27/38: {containing added animal cells (organs or tissue containing native cells A61L27/36)} - A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 27/507: {for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062)} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 27/56: Porous materials, {e.g. foams or sponges} - A61L 2400/08: Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier. ## Claims ### Claim 1 A biocompatible and biodegradable elastomer, comprising: a main chain of polyurethane comprising a hard segment and a soft segment, the hard segment is formed by reaction of diisocyanate and a chain extender, and the soft segment is a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol, polylactic acid diol, and any combinations thereof. ### Claim 2 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein the polylactic acid diol is L-lactic acid or DL-lactic acid. ### Claim 3 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein when the soft segment is consisted of polycaprolactone diol and polyethylene butylene adipate diol, the polycaprolactone diol is in an amount of greater than 0.3 molar fraction of the degradable oligomer diol. ### Claim 4 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein when the soft segment is consisted of polycaprolactone diol and polylactic acid diol, the polycaprolactone diol is in an amount of greater than 0.4 molar fraction of the degradable oligomer diol. ### Claim 5 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein when the soft segment is consisted of polycaprolactone diol and polylactic acid diol, the polycaprolactone diol is in an amount of greater than 0.8 molar fraction of the degradable oligomer diol. ### Claim 6 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein the diisocyanate is alicyclic polyisocyanate. ### Claim 7 (depends on 6) The biocompatible and biodegradable elastomer of claim 6, wherein the alicyclic polyisocyanate is isophorone diisocyanate. ### Claim 8 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein the chain extender is ethylenediamine. ### Claim 9 (depends on 1) The biocompatible and biodegradable elastomer of claim 1, wherein the amount of the soft segment is between 45% and 75% w/w of the total weight of the elstomer. ### Claim 10 (depends on 1) A biocompatible and biodegradable elastic membrane made of the biocompatible and biodegradable elastomer of claim 1, wherein the Young's modulus of the biodegradable elastic membrane is greater than 0.5 MPa and smaller than 40 MPa. ### Claim 11 (depends on 10) The biocompatible and biodegradable elastic membrane of claim 10, wherein the tensile strength of the biodegradable elastic membrane is greater than 5 MPa. ### Claim 12 (depends on 1) The biocompatible and biodegradable elastic membrane of claim 1, wherein the elongation of the biodegradable elastic membrane is greater than 400%. ### Claim 13 (depends on 1) A vascular graft made of the biocompatible and biodegradable elastomer of claim 1, wherein a plurality of pores are present on the wall of the vascular graft with an average pore diameter on the outer surface is between 5 to 50 μm, and an average pore diameter on the cross-section is between 10 to 100 μm. ### Claim 14 (depends on 13) The vascular graft of claim 13, the elongation of the vascular graft is greater than 220%. ### Claim 15 (depends on 13) The vascular graft of claim 13, wherein the pores are made by using freeze drying. ### Claim 16 (depends on 13) The vascular graft of claim 13, wherein the pores are made by using particle-leaching method. ### Claim 17 (depends on 13) The vascular graft of claim 13, wherein the surface of the wall of the vascular graft is chemically modified. ### Claim 18 (depends on 1) A carrier made of the biocompatible and biodegradable elastomer of claim 1, wherein the carrier is present in the form of microsphoere, hydrogel, nanodispersion, nanodispersion-coated inorganic nanoparticle, foam, electrospinning fiber, or scaffold. ### Claim 19 (depends on 18) The carrier of claim 18, wherein the carrier is used for carrying a cell, a gene, or a drug. ### Claim 20 (depends on 18) The carrier of claim 18, wherein the carrier exhibits electronegativity, amphiphilicity, and anticoagulant ability.