# US 2014/0194531 A1 · Hydroxytyrosol benefits mitochondria

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- Number: US 2014/0194531 A1
- Document ID: US20140194531A1
- Status: Published application
- Kind: A1
- Application number: 14/148,158
- Filed: 2014-01-06
- Published: 2014-07-10
- Earliest claimed: 2008-04-17
- Assignees: Dsm IP Assets B.V.
- Applicants: DSM IP Assets B.V.
- Inventors: Jiankang LIU; Daniel RAEDERSTORFF; Ying WANG-SCHMIDT; Karin WERTZ
- Web page: https://patentgrep.com/patent/US20140194531A1

## CPC

- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Hydroxytyrosol or olive juice containing hydroxytyrosol ca in can he used to maintain or increase mitochondria(biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

## Claims

### Claim at position 1

1-15. (canceled)

### Claim 16

A method of maintaining or increasing mitochondrial biogenesis comprising administering an effective amount of hydroxytyrosol to a mammal.

### Claim 17 (depends on 16)

A method according to claim 16 wherein the hydroxytyrosol is present in an olive juice extract.

### Claim 18 (depends on 16)

A method according to claim 16 wherein maintaining or increasing mitochondrial biogenesis results in maintaining or increasing cardiac energy, strength or endurance.

### Claim 19 (depends on 18)

A method according to claim 18 wherein increased cardiac strength results in increased blood circulation.

### Claim 20 (depends on 16)

A method according to claim 16 wherein maintaining or increasing mitochondrial biogenesis results in maintaining or increasing liver health, to assist the liver in maintaining healthy liver fat metabolism, or to maintain a healthy liver metabolism.

### Claim 21 (depends on 16)

The method according to claim 16, wherein the method improves the body shape and/or improves the muscle : fat ratio in mammals including humans.

### Claim 22

A method for improving the alertness in a mammal, characterized by that the amount of caffeine taken is reduced to 100 mg or less per day showing the same effect on the alertness as if no hydroxytyrosol is taken and no reduction of caffeine is done, said method comprising administering an effective amount of hydroxytyrosol to said mammal.

### Claim 23

A method for improving the muscle/fat ratio and to promote fat burning wherein the muscle mass increased in a mammal, said method comprising administering an effective amount of hydroxytyrosol to said mammal.

### Claim 24

Method of enhancing alertness provided by a food composition comprising adding hydroxytyrosol to said food composition.