# US 2014/0194530 A1 · Usage of oblongifolin c, a natural compound from garcinia yunnanensis hu, on treating cancer as metastasis inhibitor and autophagic flux inhibitor

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- Number: US 2014/0194530 A1
- Document ID: US20140194530A1
- Status: Published application
- Kind: A1
- Application number: 14/151,792
- Filed: 2014-01-09
- Published: 2014-07-10
- Earliest claimed: 2013-01-10
- Assignees: Hong Kong Baptist University
- Applicants: Hong Kong Baptist University
- Inventors: Hongxi Xu; Yuanzhi Lao; Hongsheng Tan; Naihan Xu; Xiaoyu Wang; Zhenyan Liu; Kaixian Chen; Zhaoxiang Bian; Dajian Yang; Shilin Chen; Aiping Lu; Albert Sun Chi Chan
- Web page: https://patentgrep.com/patent/US20140194530A1

## CPC

- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed is a natural compound, Oblongifolin C, isolated from a natural plant comprising Garcinia species such as Garcinia yunnanesis Hu, for its effects of anti-migration and anti-invasion against cancer and its use as an anticancer drug. The treated cancers comprise cervical cancers and esophageal cancers. The cancer treatment comprises inhibition of cancer metastasis and inhibition of autophagic flux.

## Claims

### Claim 1

A composition for treating cancers comprising a compound with the chemical structure of

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said compound comprising Oblongifolin C.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein said compound is isolated from a natural plant.

### Claim 4 (depends on 3)

The composition according to claim 3, wherein said natural plant comprising Garcinia species.

### Claim 5 (depends on 4)

The composition according to claim 4, wherein said Garcinia species comprising Garcinia yunnanesis Hu.

### Claim 6 (depends on 1)

The composition according to claim 1, wherein the treated cancers comprising cervical cancers and esophageal cancers.

### Claim 7 (depends on 1)

The composition according to claim 1, wherein the cancer treatment comprising inhibition of cancer metastasis and inhibition of autophagic flux.

### Claim 8 (depends on 1)

A use of the composition according to claim 1 for manufacture of anticancer medicaments.

### Claim 9 (depends on 8)

The use according to claim 8, wherein said composition is used as an autophagy inhibitor.

### Claim 10 (depends on 1)

A method of treating cancer using composition according to claim 1 by administering said composition to a subject in need of such treatment.

### Claim 11 (depends on 10)

The method according to claim 10 wherein said composition is administered by injection.