# US 2014/0194523 A1 · Desensitizing drug products and methods of use

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- Number: US 2014/0194523 A1
- Document ID: US20140194523A1
- Status: Published application
- Kind: A1
- Application number: 14/146,582
- Filed: 2014-01-02
- Published: 2014-07-10
- Earliest claimed: 2013-01-04
- Assignees: Absorption Pharmaceuticals, LLC
- Applicants: Absorption Pharmaceuticals, LLC
- Inventors: Ronald Franklin Gilbert; Jeff Abraham
- Web page: https://patentgrep.com/patent/US20140194523A1

## CPC

- A61K 31/167: having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 13/00: Drugs for disorders of the urinary system
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 23/00: Anaesthetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Desensitizing drug products, methods of making desensitizing drug products, and methods of using desensitizing drug products including delivery of desensitizing drug products are disclosed herein.

## Claims

### Claim 1

A method of treating interstitial cystitis in a patient, the method comprising:
administering to the patient a pharmaceutical composition comprising 7.7% by weight lidocaine based on the total weight of the pharmaceutical composition, 0.86% thymol based on the total weight of the pharmaceutical composition, 10% by weight ethanol based on the total weight of the pharmaceutical composition, and a base; and
relieving symptoms of interstitial cystitis.

### Claim 2 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition does not contain prilocaine.

### Claim 3 (depends on 2)

The method of claim 2, wherein the base comprises an aqueous solution, and wherein the aqueous solution comprises a pH in the range of about 7.4 to about 8.9.

### Claim 4 (depends on 3)

The method of claim 3, wherein the aqueous solution comprises a pH of about 7.4.

### Claim 5 (depends on 3)

The method of claim 3, wherein the aqueous solution comprises a pH of about 7.9.

### Claim 6 (depends on 3)

The method of claim 3, wherein the aqueous solution comprises a pH of about 8.4.

### Claim 7 (depends on 1)

The method of claim 1, wherein the administering is performed using a metered spray.

### Claim 8

A method of treating vulvodynia in a patient, the method comprising:
administering to the patient a pharmaceutical composition comprising 7.7% by weight lidocaine based on the total weight of the pharmaceutical composition, 0.86% thymol based on the total weight of the pharmaceutical composition, 10% by weight ethanol based on the total weight of the pharmaceutical composition, and a base; and
relieving symptoms of vulvodynia.

### Claim 9 (depends on 8)

The method of claim 8, wherein the pharmaceutical composition does not contain prilocaine.

### Claim 10 (depends on 9)

The method of claim 9, wherein the base comprises an aqueous solution, and wherein the aqueous solution comprises a pH in the range of about 7.4 to about 8.9.

### Claim 11 (depends on 10)

The method of claim 10, wherein the aqueous solution comprises a pH of about 7.4.

### Claim 12 (depends on 10)

The method of claim 10, wherein the aqueous solution comprises a pH of about 7.9.

### Claim 13 (depends on 10)

The method of claim 10, wherein the aqueous solution comprises a pH of about 8.4.

### Claim 14 (depends on 9)

The method of claim 9, wherein the administering is performed using a metered spray.

### Claim 15

A method of preventing pain to the breast of a patient, the method comprising:
administering to the patient a pharmaceutical composition comprising 7.7% by weight lidocaine based on the total weight of the pharmaceutical composition, 0.86% thymol based on the total weight of the pharmaceutical composition, 10% by weight ethanol based on the total weight of the pharmaceutical composition, and a base; and
preventing pain to the breast of a patient.

### Claim 16 (depends on 15)

The method of claim 15, wherein the pharmaceutical composition does not contain prilocaine.

### Claim 17 (depends on 16)

The method of claim 16, wherein the base comprises an aqueous solution, and wherein the aqueous solution comprises a pH in the range of about 7.4 to about 8.9.

### Claim 18 (depends on 16)

The method of claim 16, wherein the administering is performed using a metered spray.