# US 2014/0194522 A1 · Emulsion Composition

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- Number: US 2014/0194522 A1
- Document ID: US20140194522A1
- Status: Published application
- Kind: A1
- Application number: 14/233,550
- Filed: 2012-08-08
- Published: 2014-07-10
- Earliest claimed: 2011-08-09
- Assignees: Kao Corporation
- Inventors: Kazuhiro Kaizu; Koji Yokoyama
- Web page: https://patentgrep.com/patent/US20140194522A1

## CPC

- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/42: Amides
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/68: Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided is an emulsion composition comprising the following ingredients (A), (B), (C), (D), (E), and (F): (A) glyceryl monofatty acid ester derived from a linear-chain fatty acid having 10 to 24 carbon atoms; (B) a higher alcohol having 10 to 24 carbon atoms; (C) a ceramide; (D) an anionic surfactant; (E) a polar oil selected from branched fatty acid esters having an IOB of from 0.2 to 0.85 and having a hydroxyl group or an amino group; and (F) water, wherein the mass ratio of the total content of ingredients (A), (B), and (C) and ingredient (D) in terms of acid to the content of ingredient (E), ((A)+(B)+(C)+(D))/(E), is from 1.2 to 25.

## Claims

### Claim 1

An emulsion composition comprising the following ingredients (A), (B), (C), (D), (E), and (F):
(A) a glyceryl monofatty acid ester derived from a linear-chain fatty acid having 10 to 24 carbon atoms,
(B) a higher alcohol having 10 to 24 carbon atoms,
(C) a ceramide,
(D) an anionic surfactant,
(E) a polar oil selected from branched fatty acid esters having an IOB of from 0.2 to 0.85 and having a hydroxyl group or an amide bond, and
(F) water,
wherein the mass ratio of the total content of ingredients (A), (B), and (C) and ingredient (D) in terms of acid to the content of ingredient (E), ((A)+(B)+(C)+(D))/(E), is from 1.2 to 25.

### Claim 2 (depends on 1)

The emulsion composition according to claim 1, wherein the mass ratio of the content of ingredient (D) in terms of acid to the content of ingredient (E), (D)/(E), is from 0.1 to 5.

### Claim 3 (depends on 1)

The emulsion composition according to claim 1, further comprising a polyol (G) having an IOB of from 1.5 to 3.5.

### Claim 4 (depends on 1)

The emulsion composition according to claim 1, further comprising an oil other than ingredient (B), (C), and (E).

### Claim 5 (depends on 1)

The emulsion composition according to claim 1, wherein ingredient (A) is at least one selected from glyceryl monopalmitate, glyceryl monostearate, and glyceryl monobehenate.

### Claim 6 (depends on 1)

The emulsion composition according to claim 1, wherein ingredient (B) is at least one selected from cetanol, stearyl alcohol, and behenyl alcohol.

### Claim 7 (depends on 1)

The emulsion composition according to claim 1, wherein ingredient (C) is at least one ceramide selected from a natural-type ceramide selected from ceramide Types 1 to 7 obtained by amidation of sphingosine, dihydrosphingosine, phytosphingosine, or sphingadienine and N-alkyl forms thereof, and a pseudo-ceramide represented by formula (2):
wherein R15 represents a C10 to C22 linear-chain, branched-chain, or cyclic, and saturated or unsaturated hydrocarbon group which is optionally substituted by a hydroxyl group or represents a hydrogen atom; X9 represents a hydrogen atom, an acetyl group, or a glyceryl group; R16 represents a C5 to C22 linear-chain, branched-chain, or cyclic, and saturated or unsaturated hydrocarbon group which is optionally substituted by a hydroxyl group or an amino group, or such a hydrocarbon group to which a C8 to C22 linear-chain or branched-chain and saturated or unsaturated fatty acid which is optionally substituted by a hydroxyl group is bonded at the ω-end via ester bonding; and R17 represents a hydrogen atom or an alkyl group optionally substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, or an acetoxy group and containing 1 to 30 carbon atoms in total.

### Claim 8 (depends on 1)

The emulsion composition according to claim 1, wherein ingredient (D) is at least one selected from a sodium salt and an arginine salt of an acid selected from fatty acid amidosulfonic acids derived from fatty acids having 18 to 22 carbon atoms, polyoxyethylene alkyl ether phosphoric acids having C18-C22 alkyl groups, and N-acylglutamic acids derived from fatty acids having 18 to 22 carbon atoms.

### Claim 9 (depends on 1)

The emulsion composition according to claim 1, wherein the mass ratio of the content of ingredient (B) to the content of ingredient (C), (B)/(C), is from 0.2 to 5.

### Claim 10 (depends on 3)

The emulsion composition according to claim 3, wherein the mass ratio of the total content of ingredients (A), (B), and (C) and ingredient (D) in terms of acid to the content of ingredient (G), ((A)+(B)+(C)+(D))/(G), is from 0.1 to 20.

### Claim 11 (depends on 1)

The emulsion composition according to claim 1, wherein the content of the oil having an IOB of from 0.1 to 0.2 other than ingredient (E) is 5% by mass or less.

### Claim 12 (depends on 1)

A method of producing the emulsion composition according to claim 1, the method comprising a step of heating and mixing ingredients (A) to (D) before a step of addition and mixing of ingredient (E).

### Claim 13 (depends on 12)

The method according to claim 12, comprising a step of neutralizing an acid compound of ingredient (D) with a base before the step of addition and mixing of ingredient (E).

### Claim 14 (depends on 1)

A method of producing the emulsion composition according to claim 1, the method comprising a step of heating and stirring a first oil phase containing ingredients (A), (B), and (C) and an acid compound of ingredient (D) for mixing them and a step of heating a first water phase containing a base for neutralizing ingredient (D) and part of ingredient (F) an adding the first water phase to the first oil phase and mixing them.

### Claim 15 (depends on 14)

The method according to claim 14, comprising a step of heating ingredient (E) and oily ingredients other than the first oil phase and further adding and mixing.

### Claim 16 (depends on 1)

A method for using the emulsion composition according to claim 1, the method comprising applying it to the skin.

### Claim 17 (depends on 1)

The emulsion composition according to claim 1, wherein ingredient (E) is at least one branched fatty acid ester selected from octyldodecyl lactate, difatty acid glyceryl ester composed of isostearic acid and myristic acid, diglyceryl diisostearate and di(cholesteryl/octyldodecyl) N-lauroyl-L-glutamate.
