# US 2014/0194516 A1 · Medicaments Containing Pantothenic Acid

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- Number: US 2014/0194516 A1
- Document ID: US20140194516A1
- Status: Published application
- Kind: A1
- Application number: 13/958,972
- Filed: 2013-08-05
- Published: 2014-07-10
- Earliest claimed: 1999-09-16
- Assignees: Prototype Bioforum Ltd.
- Applicants: Prototype Bioforum Ltd.
- Inventors: Paul Sherwood; David Keith Davies
- Web page: https://patentgrep.com/patent/US20140194516A1

## CPC

- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 23/00: Anaesthetics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to medicaments and their use in the alleviation of inflammation and pain in joints.

## Claims

### Claim 1

A method of treating pain in a joint inflamed by traumatic arthritis which comprises injecting a solution comprising at least about 400 mg of pantothenic acid or a pharmaceutically acceptable salt or a derivative or prodrug thereof into the inflamed joint, or injecting the solution into a site that is next to the inflamed joint but outside the capsule of the inflamed joint.

### Claim 2 (depends on 1)

The method of claim 1, wherein the solution is injected directly into the inflamed joint.

### Claim 3 (depends on 1)

The method of claim 1, wherein the solution is injected into a site that is next to the inflamed joint but outside the capsule of the inflamed joint.

### Claim 4 (depends on 3)

The method of claim 3, wherein the solution is injected into a site that is within about 10 millimeters from the exterior surface of the capsule of the inflamed joint.

### Claim 5 (depends on 1)

The method of claim 1, wherein the pantothenic acid is in the form of a salt.

### Claim 6 (depends on 5)

The method of claim 5, wherein the salt is the calcium salt.

### Claim 7 (depends on 1)

The method of claim 1, wherein the solution is an aqueous solution.

### Claim 8 (depends on 1)

The method of claim 1, wherein the pantothenic acid or the pharmaceutically acceptable salt thereof is co-formulated with a local anaesthetic.

### Claim 9 (depends on 1)

The method of claim 1, wherein a local anaesthetic is co-administered with the pantothenic acid or the pharmaceutically acceptable salt thereof in a separate injection.

### Claim 10 (depends on 1)

The method of claim 1, wherein the solution comprises about 500 mg of calcium pantothenate.

### Claim 11 (depends on 1)

The method of claim 1, wherein the inflamed joint is a freely moving joint that is inflamed by traumatic arthritis.

### Claim 12 (depends on 1)

The method of claim 1, wherein the pantothenic acid is dextro-pantothenic acid.