# US 2014/0194499 A1 · Polyprenylated Benzoylphloroglucinols With Anticancer Activity

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- Number: US 2014/0194499 A1
- Document ID: US20140194499A1
- Status: Published application
- Kind: A1
- Application number: 14/151,791
- Filed: 2014-01-09
- Published: 2014-07-10
- Earliest claimed: 2013-01-10
- Assignees: Hong Kong Baptist University
- Applicants: Hong Kong Baptist University
- Inventors: Hongxi XU; Hong ZHANG; Yuanzhi LAO; Dandan ZHANG; Kaixian CHEN; Zhaoxiang BIAN; Chengyuan LIN; Dajian YANG; Shilin CHEN; Aiping LU; Albert Sun Chi CHAN
- Web page: https://patentgrep.com/patent/US20140194499A1

## CPC

- C07D 311/78: Ring systems having three or more relevant rings
- C07C 49/84: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Two novel polyprenylated benzoylphloroglucinol derivatives, garciesculentones A and C, are disclosed in the present invention. Garciesculentones A and C exhibit cytotoxicity and/or antimigration effect against various cancer cell lines. The experimental results of the present invention suggest that Garciesculentones A and C are useful for developing into anticancer drugs.

## Claims

### Claim 1

A composition for treating cancer comprising compounds with at least one of the following chemical structures extracted from a natural plant:

### Claim 2 (depends on 1)

The composition according to claim 1 wherein said compounds comprise polyprenylated benzoylphloroglucinol derivatives.

### Claim 3 (depends on 2)

The composition according to claim 2 wherein said polyprenylated benzoylphloroglucinol derivatives comprise Garciesculentone A and/or Garciesculentone C.

### Claim 4 (depends on 1)

The composition according to claim 1 wherein the natural plant is from the genus Garcinia.

### Claim 5 (depends on 4)

The composition according to claim 4 wherein the subspecies of genus Garcinia is Garcinia esculenta Y. H. Li.

### Claim 6 (depends on 1)

The composition according to claim 1 wherein said compounds are extracted from twigs of said plant.

### Claim 7 (depends on 1)

The composition according to claim 1 wherein the cancer treated comprises hepatoma carcinoma, breast adenocarcinoma and esophageal carcinoma.

### Claim 8 (depends on 1)

A method for preparing the composition of claim 1 comprising extracting a combined extract from dried and powdered twigs of the plant by using an organic solvent, followed by drying the combined extract under vacuum to obtain a petroleum ether-soluble part while the remaining matters are refluxed with preferably 80% EtOH which is further dried under vacuum to produce a residue which is suspended in water and extracted with EtOAc to obtain a EtOAc-soluble part, and isolating said compounds from said petroleum ether-soluble part.

### Claim 9 (depends on 1)

A method for treating cancer comprising administering the composition of claim 1 to a subject in needs thereof.