# US 2014/0194498 A1 · Polyisoprenylated tetracyclic xanthone with anticancer activity

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- Number: US 2014/0194498 A1
- Document ID: US20140194498A1
- Status: Published application
- Kind: A1
- Application number: 14/149,819
- Filed: 2014-01-08
- Published: 2014-07-10
- Earliest claimed: 2013-01-10
- Assignees: Hong Kong Baptist University
- Applicants: Hong Kong Baptist University
- Inventors: Hongxi XU; Hong ZHANG; Zhichao XI; Hongsheng TAN; Kaixian CHEN; Zhaoxiang BIAN; Dajian YANG; Shilin CHEN; Aiping LU; Albert Sun Chi CHAN
- Web page: https://patentgrep.com/patent/US20140194498A1

## CPC

- C07D 311/78: Ring systems having three or more relevant rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

A novel polyisoprenylated tetracyclic xanthone, named garciesculentone B, isolated from Garcinia esculenta Y. H. Li is disclosed in the present invention. This compound is shown to have significant cytotoxicity against various cancer cells. In addition, garciesculentone B is shown to have antimigration effect on various cancer cells such as human esophageal carcinoma cell. The experimental data supports that this compound is useful for developing into an anticancer drug.

## Claims

### Claim 1

A composition for treating cancer comprising a compound with a chemical structure of
which is extracted from a natural plant.

### Claim 2 (depends on 1)

The composition according to claim 1 wherein said compound comprises polyisoprenylated tetracyclic xanthone.

### Claim 3 (depends on 2)

The composition according to claim 2 wherein said polyisoprenylated tetracyclic xanthone comprises garciesculentone B.

### Claim 4 (depends on 1)

The composition according to claim 1 wherein the natural plant comprises a subspecies of the genus Garcinia.

### Claim 5 (depends on 4)

The composition according to claim 4 wherein the subspecies of genus Garcinia is Garcinia esculenta Y. H. Li.

### Claim 6 (depends on 1)

The composition according to claim 1 wherein said compound is extracted from the twigs of said plant.

### Claim 7 (depends on 1)

The composition according to claim 1 wherein the cancer treated comprises human hepatocellular carcinoma, breast adenocarcinoma and esophageal carcinoma.

### Claim 8 (depends on 1)

A method for preparing said composition of claim 1 comprising extracting a plant extract from dried and powdered twigs of said natural plant by using an organic solvent, followed by drying the plant extract under vacuum to obtain a petroleum ether-soluble part while the remaining matters are refluxed with 80% EtOH which is further dried under vacuum to produce a residue which is suspended in water and extracted with EtOAc to obtain a EtOAc-soluble part, and isolating said compound from said petroleum ether-soluble part.

### Claim 9

A method for treating cancer comprising administering a composition containing a compound to a subject in needs thereof, said compound having a chemical structure of
which is extracted from a natural plant.

### Claim 10 (depends on 9)

The method according to claim 9 wherein said compound comprises polyisoprenylated tetracyclic xanthone.

### Claim 11 (depends on 10)

The method according to claim 10 wherein said polyisoprenylated tetracyclic xanthone comprises garciesculentone B.

### Claim 12 (depends on 9)

The method according to claim 9 wherein the natural plant comprises a subspecies of the genus Garcinia.

### Claim 13 (depends on 12)

The method according to claim 12 wherein the subspecies of genus Garcinia is Garcinia esculenta Y. H. Li.

### Claim 14 (depends on 9)

The method according to claim 9 wherein said compound is extracted from the twigs of said plant.

### Claim 15 (depends on 9)

The method according to claim 9 wherein the cancer treated comprises human hepatocellular carcinoma, breast adenocarcinoma and esophageal carcinoma.

### Claim 16 (depends on 9)

The method of claim 9 wherein said administering is via oral, intraperitoneal injection or intravenous injection.