# US 2014/0194488 A1 · Modulation of radiation response using microrna

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- Number: US 2014/0194488 A1
- Document ID: US20140194488A1
- Status: Published application
- Kind: A1
- Application number: 13/888,624
- Filed: 2013-05-07
- Published: 2014-07-10
- Earliest claimed: 2013-01-08
- Assignees: Snu R&Db Foundation
- Applicants: Snu R&Db Foundation
- Inventors: In-Ah KIM; Bong-Jun Cho; Eun Jung Choi; Hans Hyonchang Kim; David J. Lee
- Web page: https://patentgrep.com/patent/US20140194488A1

## CPC

- A61K 31/7105: Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a technology of enhancing sensitivity to radiotherapy using microRNA, more particularly to a radiosensitizer composition comprising at least one selected from the group consisting of microRNA-26b, microRNA-203 and microRNA-200c, an anticancer supplement, and a method for enhancing sensitivity to radiotherapy of cancer cells using the same.

## Claims

### Claim 1

A method for enhancing sensitivity to radiotherapy of a brain tumor patient, comprising administering a therapeutically effective amount of at least one selected from the group consisting of microRNA-26b, microRNA-203 and microRNA-200c to the brain tumor patient.

### Claim 2 (depends on 1)

The method according to claim 1, further comprising administering a therapeutically effective amount of microRNA-7.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the microRNA is in the form of mature microRNA or precursor microRNA.

### Claim 4 (depends on 2)

The method according to claim 2, wherein the microRNA is in the form of mature microRNA or precursor microRNA.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the microRNA is included in an expression vector for intracellular delivery.

### Claim 6 (depends on 2)

The method according to claim 2, wherein the microRNA is included in an expression vector for intracellular delivery.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the brain tumor is glioma.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the method enhances sensitivity to radiotherapy through delay in DNA damage repair.

### Claim 9

A method for enhancing sensitivity to radiotherapy of brain tumor cells, comprising treating brain tumor cells with at least one selected from the group consisting of microRNA-26b, microRNA-203 and microRNA-200c.

### Claim 10 (depends on 9)

The method according to claim 9, further comprising treating brain tumor cells with microRNA-7.