# US 2014/0194478 A1 · Compositions for treatment of cancer

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- Number: US 2014/0194478 A1
- Document ID: US20140194478A1
- Status: Published application
- Kind: A1
- Application number: 13/801,948
- Filed: 2013-03-13
- Published: 2014-07-10
- Earliest claimed: 2013-01-04
- Assignees: NovaRx
- Applicants: NovaRx Corporation
- Inventors: Feridoun KARIMI-BUSHERI; Habib FAKHRAI
- Web page: https://patentgrep.com/patent/US20140194478A1

## CPC

- C07D 213/59: with at least one of the bonds being to sulfur
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Compounds that are specifically toxic to cancer stem cells are disclosed.

## Claims

### Claim 1

A pharmaceutical composition comprising as an active ingredient a compound of formula (1)
R1 and R4 are non-interfering substituents independently selected from the group consisting of halo, nitro, OR2, OCOR2, COOR2, R2NCOR2, CONR22, COR2, NR22, S(0)mR2, —CN and R3,
where each R2 is independently H or alkyl (1-4)
R3 is alkyl (1-6) or substituted alkyl (1-6) wherein the substituents are halo, OR2 or NR22,
n is 0, 1 or 2,
m is 0, 1 or 2,
p is 0 or 1,
each X1-X4 is independently N or CR2, wherein at least one of X1-X4 is N,
Y is O or S or NH, and
Z is OR2, NR22 or S(O)mR2,
or the pharmaceutically acceptable salts thereof.

### Claim 2 (depends on 1)

The composition of claim 1 wherein X1 is N and X2-X4 are CR2.

### Claim 3 (depends on 1)

The composition of claim 1 wherein Z is SR2.

### Claim 4 (depends on 1)

The composition of claim 1 wherein Y is S.

### Claim 5 (depends on 1)

The composition of claim 1 wherein n and p are O, Y is S, Z is SCH3, X1 is N and X2-X4 are CH.

### Claim 6 (depends on 1)

A method to treat cancer in a subject in need thereof which comprises administering to said subject an effective amount of the composition of claim 1 or at least one compound of formula (1) or its salt.