# US 2014/0194475 A1 · Animal parasite-control method using insect growth regulators > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194475 A1 - Document ID: US20140194475A1 - Status: Published application - Kind: A1 - Application number: 14/204,905 - Filed: 2014-03-11 - Published: 2014-07-10 - Earliest claimed: 2007-09-06 - Assignees: The Hartz Mountain Corporation - Applicants: The Hartz Mountain Corporation - Inventors: William Ecker; Lance Hemsarth - Web page: https://patentgrep.com/patent/US20140194475A1 ## CPC - A61K 31/4402: only substituted in position 2, e.g. pheniramine, bisacodyl - A01N 43/40: six-membered rings - A01N 49/00: Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group [IMAGE cpc-sch-A01N-0948.gif], wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group [IMAGE cpc-sch-A01N-0949.gif], wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof (containing hydrocarbons A01N27/00) - A61K 31/09: having two or more such linkages - A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate - A61K 31/231: having one or two double bonds - A61K 31/415: 1,2-Diazoles - A61P 33/00: Antiparasitic agents - A61P 33/14: Ectoparasiticides, e.g. scabicides - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Methods and formulations for treating animal ectoparasites, effective against parasites such as fleas and ticks are provided. The methods comprise topically co-administering a non-mobile insect growth regulator and a mobile insect growth regulator to the animal. Parasiticidal formulations for treating animal ectoparasites are also provided, which can be safe to use and avoid the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of two insect growth regulators, a non-mobile insect growth regulator and a mobile insect growth regulator. The topical formulation can be packaged with the two insect growth regulators together or packaged to prevent mixing of the two insect growth regulators prior to administering the topical insecticide formulation to the animal. ## Claims ### Claim 1 An insecticidal formulation, comprising: a mobile insect growth regulator component comprising methoprene or hydroprene, which is capable of translocating from one area to another area by vaporizing and redepositing, and a non-mobile insect growth regulator component comprising pyriproxyfen, the methoprene or hydroprene and the pyriproxyfen combined in a synergistically effective amount to reduce a parasitic infestation more effectively than using the same total quantity of either insect growth regulator separately. ### Claim 2 (depends on 1) The insecticidal formulation of claim 1, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total formulation ### Claim 3 (depends on 1) The insecticidal formulation of claim 1, wherein the amount of pyriproxyfen is between 0.005% and 5% by weight of the total formulation ### Claim 4 (depends on 1) The insecticidal formulation of claim 1, wherein a weight ratio of methoprene or hydroprene to pyriproxyfen is in the range of 20:1 to 1:20. ### Claim 5 (depends on 1) The insecticidal formulation of claim 1, wherein the mobile insect growth regulator component comprises methoprene. ### Claim 6 (depends on 1) The insecticidal formulation of claim 1, wherein the mobile insect growth regulator component comprises hydroprene. ### Claim 7 (depends on 1) The insecticidal formulation of claim 1, further comprising 1% to 99% by weight of a carrier. ### Claim 8 (depends on 7) The insecticidal formulation of claim 7, wherein the carrier is an N,N dialkyl fatty acid amide. ### Claim 9 (depends on 7) The insecticidal formulation of claim 7, wherein the carrier is N,N dimethyl octanamide. ### Claim 10 (depends on 7) The insecticidal formulation of claim 7, wherein the carrier is diisopropyl adipate (DIPA). ### Claim 11 (depends on 1) The insecticidal formulation of claim 1, further comprising n-octyl pyrrolidone. ### Claim 12 (depends on 1) The insecticidal formulation of claim 1, wherein the mobile insect growth regulator component and the non-mobile insect growth regulator component are packaged to prevent their mixing prior to administration, and to permit their dispensing simultaneously or nearly simultaneously onto the animal. ### Claim 13 (depends on 1) A method of treating parasitic infestation in a non-human animal, the method comprising topically administering to the animal the insecticidal formulation of claim 1. ### Claim 14 (depends on 2, 13) The method of claim 13, comprising topically administering to the animal the insecticidal formulation of claim 2. ### Claim 15 A method of treating parasitic infestation in a non-human animal, the method comprising topically co-administering to the animal a mobile insect growth regulator component comprising methoprene or hydroprene, which is capable of translocating from one area to another area by vaporizing and redepositing, and a non-mobile insect growth regulator component comprising pyriproxyfen. ### Claim 16 (depends on 15) The method of claim 15, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total administration. ### Claim 17 (depends on 15) The method of claim 15, wherein the amount of pyriproxyfen is between 0.005% and 5% by weight of the total administration. ### Claim 18 (depends on 15) The method of claim 15, wherein the mobile insect growth regulator component comprises methoprene. ### Claim 19 (canceled) ### Claim 20 (depends on 15) The method of claim 15, wherein the mobile insect growth regulator component and the non-mobile insect growth regulator component are applied to the animal in a single combined formulation. ### Claim 21 (depends on 15) The method of claim 15, wherein the mobile insect growth regulator component and the non-mobile insect growth regulator component are separated to prevent mixing prior to administration, and are dispensed simultaneously or nearly simultaneously onto the animal. ### Claim 22 (depends on 15) The method of claim 15, further comprising applying the mobile insect growth regulator component and the non-mobile insect growth regulator component to a surface in the animal's surroundings. ### Claim 23 (depends on 1) The insecticidal formulation of claim 1, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total formulation and the amount of pyriproxyfen is between 0.005% and 5% by weight of the total formulation. ### Claim 24 (depends on 23) The method of claim 23, wherein the mobile insect growth regulator component comprises methoprene. ### Claim 25 (depends on 23) The insecticidal formulation of claim 23, wherein the mobile insect growth regulator component comprises hydroprene. ### Claim 26 (depends on 1) The insecticidal formulation of claim 1, further comprising an adulticide, effective to kill adult parasites. ### Claim 27 (depends on 24) The insecticidal formulation of claim 24, further comprising an adulticide, effective to kill adult parasites. ### Claim 28 (depends on 15) The method of claim 15, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total formulation and the amount of pyriproxyfen is between 0.005% and 5% by weight of the total formulation. ### Claim 29 (depends on 28) The method of claim 28, wherein the mobile insect growth regulator component comprises methoprene. ### Claim 30 (depends on 15) The method of claim 15, further comprising an adulticide, effective to kill adult parasites. ### Claim 31 (depends on 28) The method of claim 28, further comprising an adulticide, effective to kill adult parasites.