# US 2014/0194400 A1 · Nasal Pharmaceutical Formulation

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- Number: US 2014/0194400 A1
- Document ID: US20140194400A1
- Status: Published application
- Kind: A1
- Application number: 14/122,561
- Filed: 2012-05-24
- Published: 2014-07-10
- Earliest claimed: 2011-05-27
- Assignees: MEDA Pharma GmbH & Co. KG
- Inventors: Annegret Hildebrand-Cyrener; Joachim Maus; Ullrich Munzel; Hans Tritschler; Mario Weingart
- Web page: https://patentgrep.com/patent/US20140194400A1

## CPC

- A61K 9/0043: {Nose}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 27/02: Ophthalmic agents
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a nasel formulation comprising as its active ingredient an intranasal corticosteroid, and also to a method for prophylaxis or treatment of seasonal or perennial allergic and non-allergic rhinitis and rhinoconjunctivitis.

## Claims

### Claim 1

A nasal pharmaceutical formulation comprising fluticasone or a pharmaceutically acceptable ester or salt thereof and optionally one or more auxiliaries.

### Claim 2 (depends on 1)

The formulation as claimed in claim 1, characterized in that fluticasone propionate is used.

### Claim 3 (depends on 1)

The formulation as claimed in claim 1, wherein one or more auxiliaries are present from the group consisting of suspension agents, chelating agents, wetting agents, osmotically active substances and preservatives.

### Claim 4 (depends on 3)

The formulation as claimed in claim 3, wherein the suspension agent present is microcrystalline cellulose and Na carboxy-methylcellulose (Avicel CL 611).

### Claim 5 (depends on 3)

The formulation as claimed in claim 3, wherein the chelating agent present is disodium edetate.

### Claim 6 (depends on 3)

The formulation as claimed in claim 3, wherein the wetting agent present is polysorbate 80.

### Claim 7 (depends on 3)

The formulation as claimed in claim 3, wherein the osmotically active substance present is glycerol.

### Claim 8 (depends on 3)

The formulation as claimed in claim 3, wherein at least one preservative is present from the group comprising benzalkonium chloride and phenylethyl alcohol.

### Claim 9 (depends on 1)

The formulation as claimed in claim 1, wherein the formulation is administered by means of a spray pump.

### Claim 10 (depends on 1)

A method for the prophylaxis or treatment of allergies seasonal or perennial rhinitis, comprising administering a pharmaceutically effective amount of the formulation as claimed in claim 1, for the prophylaxis or treatment of allergic seasonal or perennial rhinitis or rhinoconjunctivitis.