# US 2014/0194378 A1 · Methods of Preventing or Treating Diseases and Conditions Using Complex Carbohydrates

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- Number: US 2014/0194378 A1
- Document ID: US20140194378A1
- Status: Published application
- Kind: A1
- Application number: 13/737,008
- Filed: 2013-01-09
- Published: 2014-07-10
- Earliest claimed: 2013-01-09
- Assignees: Dermal Research Laboratories, Inc.
- Applicants: Dermal Research Laboratories, Inc.
- Inventors: Harold G. Brown; Karen K. Brown; Carol A. Cooper
- Web page: https://patentgrep.com/patent/US20140194378A1

## CPC

- A61K 31/728: Hyaluronic acid
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0017: {Non-human animal skin, e.g. pour-on, spot-on}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention relates to a method of preventing and treating diseases and conditions associated with allergies, autoimmunity, the adhesion cascade, the metastatic cascade or the coronary cascade comprising administering (i) at least one complex carbohydrate as the sole active ingredient, or (ii) at least one pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and an effective amount of at least one transdermal or transmucosal carrier in an amount effective to deliver the complex carbohydrate into the blood stream.

## Claims

### Claim 1

A method of treating at least one inflammation-based disease or condition selected from the group consisting of asthma, anaphylaxis, allergy and emphasema, comprising administering hyaluronic acid or a salt thereof to a patient in need thereof, wherein the hyaluronic acid or salt thereof comprises at least one fraction having a molecular weight of greater than 1,000,000 daltons and wherein hyaluronic acid or salt thereof is administered orally or mucosally.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the hyaluronic aid or salt thereof is administered parenterally.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the composition is administered with at least one transmucosal carrier in an amount effective to treat said at least one inflammation-based disease or condition.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the hyaluronic acid or salt thereof is of low purity or cosmetic grade.

### Claim 5 (depends on 1)

The method of claim 1, wherein said at least one inflammation-based disease or condition is asthma.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said at least one inflammation-based disease or condition is anaphylaxis.

### Claim 7 (depends on 1)

The method according to claim 1, wherein said at least one inflammation-based disease or condition is allergy.

### Claim 8 (depends on 1)

The method according to claim 1, wherein said at least one inflammation-based disease or condition is emphasema.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the hyaluronic aid or salt thereof is administered orally.