# US 2014/0194348 A1 · Method of inhibiting papillomavirus proliferation and treating papillomavirus infection > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194348 A1 - Document ID: US20140194348A1 - Status: Published application - Kind: A1 - Application number: 14/148,980 - Filed: 2014-01-07 - Published: 2014-07-10 - Earliest claimed: 2013-01-07 - Assignees: University of Rochester - Inventors: William Bonnez - Web page: https://patentgrep.com/patent/US20140194348A1 ## CPC - A61K 38/162: {from virus} - A61K 39/12: Viral antigens - A61K 2039/5258: {Virus-like particles} - C12N 2710/20034: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) ## Abstract Methods for inhibiting virus proliferation and treating an individual having a papillomavirus infection preventing viral infection are disclosed. The methods include the steps of providing a composition comprising a plurality of papillomavirus virus-like particles or capsomeres and contacting papillomavirus-infected tissue of an individual with the composition under conditions effective to inhibit papillomavirus proliferation or treat the papillomavirus infection in the individual. ## Claims ### Claim 1 A method of inhibiting papillomavirus proliferation in an individual having a papillomavirus infection, the method comprising: providing a composition comprising a plurality of papillomavirus virus-like particles or capsomeres; and contacting papillomavirus-infected tissue of an individual with the composition under conditions effective to inhibit papillomavirus proliferation in the individual. ### Claim 2 (depends on 1) The method according to claim 1, wherein the papillomavirus-infected tissue is a lesion or tumor. ### Claim 3 (depends on 2) The method according to claim 2, wherein the lesion is a wart, papilloma, or pre-cancerous lesion. ### Claim 4 (depends on 3) The method according to claim 3, wherein the wart is a cutaneous wart, head and neck area papilloma, wart or condyloma, ano-genital wart, or an epidermodysplasia verruciformis lesion. ### Claim 5 (depends on 3) The method according to claim 3, wherein the pre-cancerous lesion is a vulvar, vaginal, anal, cervical, penile, external genitalia, urethra, bladder, or head and neck area lesion. ### Claim 6 (depends on 1) The method according to claim 1, wherein the papillomavirus virus-like particles or capsomeres comprise an L1 polypeptide and optionally an L2 polypeptide. ### Claim 7 (depends on 1) The method according to claim 1, wherein the contacted papillomavirus-infected tissue is an ano-genital tissue or an oral tissue. ### Claim 8 (depends on 1) The method according to claim 1, wherein said contacting is carried out by administering the composition sublesionally, intralesionally, perilesionally, or systemically. ### Claim 9 (depends on 1) The method according to claim 1, wherein said contacting is effective to reduce the extent or size of papillomavirus-infected tissue. ### Claim 10 (depends on 1) The method according to claim 1, wherein said contacting is effective to inhibit growth of the papillomavirus-infected tissue. ### Claim 11 (depends on 1) The method according to claim 1, wherein said contacting is effective to inhibit formation of new lesions in tissue adjacent to papillomavirus-infected tissue. ### Claim 12 A method of treating an individual having a papillomavirus infection, the method comprising: providing a composition comprising a plurality of papillomavirus virus-like particles or capsomeres; and contacting papillomavirus-infected tissue of the individual with the composition under conditions effective to treat the papillomavirus infection in the individual. ### Claim 13 (depends on 12) The method according to claim 12, wherein the papillomavirus-infected tissue is a lesion or tumor. ### Claim 14 (depends on 13) The method according to claim 13, wherein the lesion is a wart, papilloma, or pre-cancerous lesion. ### Claim 15 (depends on 14) The method according to claim 14, wherein the wart is a cutaneous wart, head and neck area papilloma, wart or condyloma, ano-genital wart, or an epidermodysplasia verruciformis lesion. ### Claim 16 (depends on 14) The method according to claim 14, wherein the pre-cancerous lesion is a vulvar, vaginal, anal, cervical, penile, external genitalia, urethra, bladder, or head and neck area lesion. ### Claim 17 (depends on 12) The method according to claim 12, wherein the papillomavirus virus-like particles or capsomeres comprise an L1 polypeptide and optionally an L2 polypeptide. ### Claim 18 (depends on 12) The method according to claim 12, wherein the contacted papillomavirus-infected tissue is an ano-genital tissue or an oral tissue. ### Claim 19 (depends on 12) The method according to claim 12, wherein said contacting is carried out by administering the composition sublesionally, intralesionally, perilesionally, or systemically. ### Claim 20 (depends on 12) The method according to claim 12, wherein said contacting is effective to reduce the extent or size of papillomavirus-infected tissue. ### Claim 21 (depends on 12) The method according to claim 12, wherein said contacting is effective to inhibit growth of the papillomavirus-infected tissue. ### Claim 22 (depends on 12) The method according to claim 12, wherein said contacting is effective to inhibit formation of new lesions in tissue adjacent to papillomavirus-infected tissue.