# US 2014/0194344 A1 · Fusion peptide designed to reduce plaque bacteria and yeast in the oral cavity > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0194344 A1 - Document ID: US20140194344A1 - Status: Published application - Kind: A1 - Application number: 14/113,245 - Filed: 2012-04-23 - Published: 2014-07-10 - Earliest claimed: 2011-04-22 - Assignees: Rutgers, The State University of New Jersey - Inventors: Daniel H. Fine; Kabilan Velliyagounder - Web page: https://patentgrep.com/patent/US20140194344A1 ## CPC - A61K 38/16: Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)} - A23L 33/18: Peptides; Protein hydrolysates - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 31/04: Antibacterial agents - C07K 14/001: {by chemical synthesis} - C07K 14/21: from Pseudomonadaceae (F) - C07K 14/79: Transferrins, e.g. lactoferrins, ovotransferrins - A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) - C07K 2319/00: Fusion polypeptide - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) ## Abstract The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and PAK fusion peptides (PAK-LF), along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease. ## Claims ### Claim 1 A composition for inhibiting bacterial growth in the oral cavity comprising a fusion peptide comprising: i. a lysine form of a Lactoferrin polypeptide or a functionally equivalent peptide molecule thereof; and ii. a PAK polypeptide or a functionally equivalent peptide molecule thereof. ### Claim 2 (canceled) ### Claim 3 (depends on 1) The composition of claim 1, wherein the composition further comprises a pharmaceutically acceptable excipient. ### Claim 4 (depends on 1) The composition of claim 1, wherein the composition further comprises a surfactant, or a surfactant-like molecule. ### Claim 5 (depends on 4) The composition of claim 4, wherein the surfactant is sodium butyl sulfate. ### Claim 6 (depends on 5) The composition of claim 5, wherein the sodium lauryl sulfate is present in an effective amount to allow the composition to penetrate biofilm. ### Claim 7 (depends on 1) The composition of claim 1, wherein the fusion peptide further comprises an additional polypeptide sequence. ### Claim 8 (depends on 3) The composition of claim 3, wherein the composition is a dosage form selected from the group consisting of a food, a food additive, dentifrices, gels, toothpaste, mouthwash, aerosol spray, pump spray, dental floss, denture wash, demure adhesives, chewing gum, candy, chewable tablets and solution. ### Claim 9 (depends on 1) The composition of claim 1, further comprising an antibacterial agent, an antimicrobial agent, an antifungal agent, anti-candidal agent, or a combination thereof. ### Claim 10 (depends on 1) A method for inhibiting bacteria and/or yeast in the oral cavity comprising administering an effective amount of the composition of claim 1 ii. to a patient in need thereof. ### Claim at position 11 -15. (canceled) ### Claim 16 (depends on 10) The method of claim 10, wherein the composition further comprises a pharmaceutically acceptable excipient. ### Claim 17 (depends on 10) The method of claim 10, wherein the composition further comprises a surfactant, or a surfactant-like molecule. ### Claim 18 (depends on 17) The method of claim 17, wherein the surfactant is sodium lauryl sulfate. ### Claim 19 (depends on 18) The method of claim 18, wherein the sodium lauryl sulfate is in an effective amount to allow the composition to penetrate bio film. ### Claim 20 (depends on 10) The method of claim 10, wherein the composition is administered via a dosage form selected from the group consisting of a food, a food additive, dentifrices, gels, toothpaste, mouthwash, dental floss, denture wash, denture adhesives, chewing gum, candy, chewable tablets and solution. ### Claim 21 (depends on 10) The method of claim 10, wherein the composition further comprises an antibacterial agent, an antimicrobial agent, antifungal agent, anti-candidal agent, or a combination thereof. ### Claim 22 (depends on 10) The method of claim 10, wherein the fusion peptide is linked to an additional polypeptide sequence. ### Claim 23 (depends on 24) A composition for inhibiting bacterial growth in the oral cavity comprising the fusion peptide of claim 24. ### Claim 24 A fusion peptide having SEQ ID NO. 5, or a functionally equivalent peptide molecule thereof. ### Claim 25 A nucleic acid encoding an amino acid comprising SEQ ID NO. 5. ### Claim at position 22 -27. (canceled) ### Claim 28 (depends on 1) The composition of claim 1, further comprising a statherin polypeptide comprising SEQ ID NO: 2. ### Claim 29 (depends on 1) The composition of claim 1, further comprising a STAT-LF fusion peptide comprising: i. a lysine form of a Lactoferrin polypeptide or a functionally equivalent peptide molecule thereof; and ii. a Statherin polypeptide or a functionally equivalent peptide molecule thereof. ### Claim 30 (depends on 29) The composition of claim 29, wherein the STAT-LF fusion peptide comprises SEQ ID NO: 3. ### Claim 31 (depends on 1) The composition of claim 1, wherein the PAK polypeptide comprises a fragment of SEQ ID NO: 6. ### Claim 32 (depends on 31) The composition of claim 31, wherein the PAK polypeptide comprises at least 17 amino acids. ### Claim at position 28 -36. (canceled)