# US 2014/0194340 A1 · Diagnosing, monitoring and treating inflammation

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- Number: US 2014/0194340 A1
- Document ID: US20140194340A1
- Status: Published application
- Kind: A1
- Application number: 14/109,550
- Filed: 2013-12-17
- Published: 2014-07-10
- Earliest claimed: 2006-11-10
- Assignees: The Brigham and Women's Hospital, Inc.
- Applicants: The Brigham and Women's Hospital, Inc.
- Inventors: Mark W. Feinberg
- Web page: https://patentgrep.com/patent/US20140194340A1

## CPC

- A61K 38/1709: {from mammals}
- A61L 31/047: {Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- G01N 33/505: {involving T-cells}
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/41: Anti-inflammatory agents, e.g. NSAIDs
- G01N 2333/4703: Regulators; Modulating activity
- G01N 2333/70514: CD4
- G01N 2333/7155: for interleukins [IL]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.

## Claims

### Claim 1

A method for treating a chronic inflammatory disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a KLF 10 polypeptide or fragment thereof, wherein the KLF10 polypeptide or fragment thereof induces a T regulatory phenotype.