# US 2014/0193889 A1 · Enzymatic antimicrobial and antifouling coatings and polymeric materials

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- Number: US 2014/0193889 A1
- Document ID: US20140193889A1
- Status: Published application
- Kind: A1
- Application number: 14/151,455
- Filed: 2014-01-09
- Published: 2014-07-10
- Earliest claimed: 2002-09-09
- Assignees: Reactive Surfaces Ltd., LLP
- Applicants: Reactive Surfaces, Ltd.
- Inventors: C. Steven McDaniel
- Web page: https://patentgrep.com/patent/US20140193889A1

## CPC

- C09D 5/1637: {Macromolecular compounds}
- A61L 2/00: Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- C09D 5/00: Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced {(electrically insulating plastics, resins or waxes H01B3/30)}; Filling pastes
- C09D 5/14: Paints containing biocides, e.g. fungicides, insecticides or pesticides (C09D5/16 takes precedence)
- C09D 5/30: Camouflage paints
- C09J 11/08: Macromolecular additives
- A62D 2101/02: Chemical warfare substances, e.g. cholinesterase inhibitors
- A62D 2101/45: containing nitrogen or phosphorus
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H)
- A62D: CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS

## Abstract

Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or in combination with other enzymes such as a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme, or an antimicrobial peptide. Also disclosed herein are methods of retarding or preventing microbial growth on or in a coating, paint, textile finish, wax, elastomer, adhesive, sealant, filler, or a polymeric material, where such a surface material includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase).

## Claims

### Claim at position 1

1-187. (canceled)

### Claim 188

A method of promoting the removal of a lipid on a surface or a coating comprising:
providing a surface or a coating;
associating a lipase with said surface or said coating such that said lipase is capable of enzymatically degrading a lipid component of a surface contaminant, and
promoting the removal of a lipid component of a surface contaminant at ambient to baking temperatures from the lipase associated surface or coating when contacted by the lipid component of a surface contaminant.

### Claim 189

A method of promoting the removal of a surface contaminant on a surface or a coating comprising:
providing a surface or a coating;
associating a lipase with said surface or said coating such that said lipase is capable of enzymatically degrading a lipid component of a surface contaminant, and
promoting the removal of a surface contaminant at ambient to baking temperatures from the lipase associated surface or coating when contacted by the surface contaminant.

### Claim 190

A method for promoting removal of a biomolecule composition from a surface comprising:
providing a curable polymeric coating comprising a binder, a surfactant, a non-aqueous organic diluent for the binder, and a cross-linking binder;
dispersing an amylase or functional equivalent thereof having amylase activity within said curable polymeric coating;
curing said curable polymeric coating such that said amylase or functional equivalent thereof having amylase activity is capable of enzymatically cleaving a component of said biomolecule composition when contacting said curable polymeric coating; and
contacting said curable polymeric coating with said biomolecule composition.

### Claim 191

A composition for removing chemicals from a solid surface comprising:
a digestive enzyme capable of enzymatically altering a chemical,
a surface treatment applied to the solid surface, and
a linker moiety bound to an outer surface of said surface treatment and an moiety of said digestive enzyme, said linker moiety between said enzyme and said surface treatment and covalently linking said enzyme to a surface of said surface treatment,
said digestive enzyme forming a layer on a surface of said surface treatment such that the digestive enzyme is surface exposed for reaction with a chemical.

### Claim 192 (depends on 191)

A process for self-removal of a chemical, comprising:
applying a surface treatment to a surface; and
forming a linker moiety between a moiety of a digestive enzyme and said surface treatment so as to form the composition of claim 191.