# US 2014/0193874 A1 · Novel biomarker for diagnosis of lung cancer

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- Number: US 2014/0193874 A1
- Document ID: US20140193874A1
- Status: Published application
- Kind: A1
- Application number: 14/146,818
- Filed: 2014-01-03
- Published: 2014-07-10
- Earliest claimed: 2013-01-04
- Assignees: Seoul National University R&Db Foundation
- Applicants: Seoul National University R&DB Foundation
- Inventors: Je Yoel CHO
- Web page: https://patentgrep.com/patent/US20140193874A1

## CPC

- C12N 9/20: Triglyceride splitting, e.g. by means of lipase
- G01N 33/5752: of the lungs
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Disclosed are a composition for diagnosis of lung cancer including an antibody specific to GPI specific phospholipase D1 (GPLD1) protein, which is an effective biomarker for early diagnosis of lung cancer, and a composition for diagnosis of lung cancer including a primer or probe specific to a nucleic acid encoding the GPLD1 protein. The lung cancer diagnostic marker may be effectively used in early diagnosis of lung cancer and also, is very useful for evaluating progression of a disease and prognosis before and after treatment of the same.

## Claims

### Claim 1

A composition for diagnosis of lung cancer, comprising an antibody or polypeptide specifically bound to glycosylphosphatidylinositol (GPI) specific phospholipase D1 (GPLD1) protein.

### Claim 2

A kit for diagnosis of lung cancer, comprising an antibody or polypeptide specifically bound to GPLD1 protein.

### Claim 3

A micro-array for diagnosis of lung cancer, comprising an antibody or polypeptide specifically bound to GPLD1 protein.

### Claim 4

A protein chip for diagnosis of lung cancer, comprising an antibody or polypeptide specifically bound to GPLD1 protein.

### Claim 5

A composition for diagnosis of lung cancer, comprising a primer or probe specific to a nucleic acid encoding GPLD1 protein.

### Claim 6

A kit for diagnosis of lung cancer, comprising a primer or probe specific to a nucleic acid encoding GPLD1 protein.

### Claim 7

A micro-array for diagnosis of lung cancer, comprising a primer or probe specific to a nucleic acid encoding GPLD1 protein.

### Claim 8

A DNA chip for diagnosis of lung cancer, comprising a primer or probe specific to a nucleic acid encoding GPLD1 protein.