# US 2014/0193799 A1 · Microfabricated artificial lung assist device, and methods of use and manufacture thereof

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- Number: US 2014/0193799 A1
- Document ID: US20140193799A1
- Status: Published application
- Kind: A1
- Application number: 14/177,799
- Filed: 2014-02-11
- Published: 2014-07-10
- Earliest claimed: 2010-05-26
- Assignees: The Charles Start Draper Laboratory, Inc.
- Applicants: The Charles Start Draper Laboratory, Inc.
- Inventors: Jeffrey T. Borenstein; Joseph L. Charest; James Ching-Ming Hsiao; Tatiana Kniazeva
- Web page: https://patentgrep.com/patent/US20140193799A1

## CPC

- A61M 1/1698: {Blood oxygenators with or without heat-exchangers (intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00)}
- A61M 1/3644: {Mode of operation}
- B01D 63/081: {Manufacturing thereof}
- B01D 63/0821: {Membrane plate arrangements for submerged operation}
- B01D 63/084: {at least one flow duct intersecting the membranes}
- B01D 63/088: {Microfluidic devices comprising semi-permeable flat membranes}
- B01D 71/701: {Polydimethylsiloxane}
- A61M 1/3606: {Arrangements for blood-volume reduction of extra-corporeal circuits}
- A61M 1/3643: {Priming, rinsing before or after use}
- A61M 2205/0244: Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
- B33Y 80/00: Products made by additive manufacturing
- Y02C 20/40: of CO2
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- Y02C: CAPTURE, STORAGE, SEQUESTRATION OR DISPOSAL OF GREENHOUSE GASES [GHG]

## Abstract

The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

## Claims

### Claim at position 1

1-40. (canceled)

### Claim 41

An extracorporeal membrane oxygenator device, comprising a plurality of bi-layer structures arranged in a stack, each bi-layer structure comprising:
a first polymer layer defining a plurality of blood flow channels within a surface thereof, wherein at least a subset of the plurality of blood flow channels each have a plurality of ribs running along at least a portion of their respective lengths;
a second polymer layer defining a plurality of gas flow channels within a surface thereof, wherein the second polymer layer is aligned with the first polymer layer such that the plurality of gas flow channels overlap the plurality of blood flow channels; and
a gas permeable membrane coupled between the surface of the first polymer layer and the surface of the second polymer layer and supported by the plurality of ribs included in the subset of the plurality of blood flow channels.

### Claim 42 (depends on 41)

The device of claim 41, wherein each of the plurality of ribs are about 100 μm wide.

### Claim 43 (depends on 41)

The device of claim 41, wherein all of the plurality of blood flow channels each have a plurality of ribs running along at least a portion of their respective lengths.

### Claim 44 (depends on 41)

The device of claim 41, wherein a height of the plurality of blood flow channels is between about 10 μm and about 150 μm.

### Claim 45 (depends on 41)

The device of claim 41, wherein a height of the plurality of blood flow channels is between about 10 μm and about 50 μm.

### Claim 46 (depends on 41)

The device of claim 41, wherein the plurality of gas flow channels include at least one post.

### Claim 47 (depends on 41)

The device of claim 41, wherein a thickness of the gas permeable membrane is less than 10 μm.

### Claim 48 (depends on 41)

The device of claim 41, wherein the width of each of the plurality of gas flow channels spans the width of multiple blood flow channels.

### Claim 49 (depends on 41)

The device of claim 41, wherein the plurality of blood flow channels have a length between about 500 μm and about 3 cm.

### Claim 50 (depends on 41)

The device of claim 41, further comprising:
a third polymer layer defining a second plurality of blood flow channels within a surface thereof, a subset of the second plurality of blood flow channels each having a plurality of ribs running along at least a portion of their respective lengths;
a fourth polymer layer defining a second plurality of gas flow channels within the surface thereof, wherein the fourth polymer layer is aligned with the second polymer layer such that the second plurality of gas flow channels overlap the second plurality of blood flow channels; and
a second gas permeable membrane coupled between the surface of the third polymer layer and the surface of a fourth polymer layer and supported by the plurality of ribs included in the subset of the second plurality of blood flow channels.

### Claim 51

A method for transferring a gas to a liquid, the method comprising:
providing a microfluidic device, the microfluidic device comprising:
a first polymer layer defining a plurality of blood flow channels within a surface thereof, wherein at least a subset of the plurality of blood flow channels each have a plurality of ribs running along at least a portion of their respective lengths;
a second polymer layer defining a plurality of gas flow channels within a surface thereof, wherein the second polymer layer is aligned with the first polymer layer such that the plurality of gas flow channels overlap the plurality of blood flow channels; and
a gas permeable membrane coupled between the surface of the first polymer layer and the surface of the second polymer layer and supported by the plurality of ribs included in the subset of the plurality of blood flow channels;
flowing blood through the plurality of blood flow channels defined in the first polymer layer; and
flowing oxygen through the plurality of gas flow channels defined in the second polymer layer.

### Claim 52 (depends on 51)

The method of claim 51, wherein each of the plurality of ribs are about 100 μm wide.

### Claim 53 (depends on 51)

The method of claim 51, wherein all of the plurality of blood flow channels each have a plurality of ribs running along at least a portion of their respective lengths.

### Claim 54 (depends on 51)

The method of claim 51, wherein a height of the plurality of blood flow channels is between about 10 μm and about 150 μm.

### Claim 55 (depends on 51)

The method of claim 51, wherein a height of the plurality of blood flow channels is between about 10 μm and about 50 μm.

### Claim 56 (depends on 51)

The method of claim 51, wherein the plurality of blood flow channels have a length between about 500 μm and about 3 cm.

### Claim 57 (depends on 51)

The method of claim 51, wherein flowing blood through the plurality of blood flow channels further comprises flowing the blood at a rate of between about 15 mL/min and about 150 mL/min.

### Claim 58 (depends on 51)

The method of claim 51, wherein a thickness of the gas permeable membrane is less than 10 μm.

### Claim 59 (depends on 51)

The method of claim 51, wherein the width of each of the plurality of gas flow channels spans the width of multiple blood flow channels.