# US 2014/0193569 A1 · Stent with preferential coating

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- Number: US 2014/0193569 A1
- Document ID: US20140193569A1
- Status: Published application
- Kind: A1
- Application number: 14/205,252
- Filed: 2014-03-11
- Published: 2014-07-10
- Earliest claimed: 2007-09-28
- Assignees: Abbott Cardiovascular Systems Inc.
- Applicants: Abbott Cardiovascular Systems Inc.
- Inventors: Bin Huang; David C. Gale; Daniel A. Castro; Vincent J. Gueriguian
- Web page: https://patentgrep.com/patent/US20140193569A1

## CPC

- A61L 31/10: Macromolecular materials
- A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61K 31/436: the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A61L 31/022: {Metals or alloys}
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61L 31/08: Materials for coatings
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- B05D 1/02: performed by spraying
- B05D 1/18: performed by dipping
- B05D 1/32: using means for protecting parts of a surface not to be coated, e.g. using stencils, resists
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0051: differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
- A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body
- A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A61L 2420/02: Methods for coating medical devices
- A61L 2420/08: Coatings comprising two or more layers
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)

## Abstract

This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.

## Claims

### Claim 1

A method for manufacturing a stent, the method comprising:
Forming a prohealing coating above an inner surface of a tube, the prohealing coating comprising a prohealing agent that promotes cell growth;
Forming a stent from the tube;
Forming an antiproliferative coating above an abluminal surface of the stent, the abluminal coating of the stent comprising an antiproliferative active agent.

### Claim 2 (depends on 1)

The method of claim 1, wherein forming the antiproliferative coating comprises masking the luminal surface with a cylindrical member, and applying a coating material to the abluminal surface of the stent body, the coating material comprising the antiproliferative active agent.

### Claim 3 (depends on 2)

The method of claim 2, wherein a solution or dispersion of the coating material is applied to the abluminal surface of the stent body by spraying or dipping.

### Claim 4 (depends on 1)

The method of claim 1, further comprising crimping the stent prior forming an antiproliferative coating above an abluminal surface of the stent, wherein the crimping allows selective application of the coating material to the abluminal surface.