# US 2014/0193521 A1 · Drug Delivery Systems and Method of Reducing Foal Infection by Treating Mares with Gallium Salts

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- Number: US 2014/0193521 A1
- Document ID: US20140193521A1
- Status: Published application
- Kind: A1
- Application number: 14/238,579
- Filed: 2012-08-10
- Published: 2014-07-10
- Earliest claimed: 2011-08-15
- Inventors: Benjamin R. Buchanan
- Web page: https://patentgrep.com/patent/US20140193521A1

## CPC

- A61K 33/24: Heavy metals; Compounds thereof
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/28: Compounds containing heavy metals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

This invention relates to drug delivery systems and methods of preventing respiratory bacterial infection in a foal of a mare. This invention relates to the reduction of transmission from the mare to the foal of bacteria though contaminated matter in the foal's environment.

## Claims

### Claim 1

A drug delivery system for reducing the concentration of pathogenic bacteria in feces of a mare, the drug delivery system comprising:
at least one gallium salt in a therapeutically effective amount and in a form that is substantially non-absorbable by a gastrointestinal system of the mare;
the at least one specific said gallium salt has an effect of reducing the concentration of pathogenic bacteria in feces of the mare as compared to feces of the mare prior to receiving the at least one gallium salt; and
a pharmaceutically acceptable carrier for delivering the at least one gallium salt to a natural orifice, throat or lungs of the mare.

### Claim 2 (depends on 1)

The drug delivery system of claim 1, wherein the pathogenic bacteria is Rhodococcus equi.

### Claim 3 (depends on 1)

The drug delivery system of claim 1, wherein the gallium salt is selected from a group consisting of gallium bromide, gallium chloride, gallium citrate, gallium fluoride, gallium iodide, gallium maltolate, gallium nitrate, gallium perchlorate, gallium sulfate, gallium phosphate, and gallium citrate.

### Claim 4

A drug delivery system for preventing respiratory bacterial infection in a foal of a mare, the delivery system comprising:
at least one gallium salt in a therapeutically effective amount and in a form that is substantially non-absorbable by a gastrointestinal system of the mare,
the at least one gallium salt has an effect of reducing a concentration of pathogenic bacteria present in feces of the mare as compared to feces of the mare prior to receiving the at least one gallium salt; and
a pharmaceutically acceptable carrier for delivering the at least one gallium salt to a natural orifice, throat or lungs of the mare.

### Claim 5 (depends on 4)

The drug delivery system of claim 4, wherein the pathogenic bacteria is Rhodococcus equi.

### Claim 6 (depends on 4)

The drug delivery system of claim 4, wherein the gallium salt is selected from a group consisting of gallium bromide, gallium chloride, gallium citrate, gallium fluoride, gallium iodide, gallium maltolate, gallium nitrate, gallium perchlorate, gallium sulfate, gallium phosphate, and gallium citrate.

### Claim 7

A method of preventing infection in a foal of a mare, the method comprising
administering to the mare a drug delivery system comprising
at least one gallium salt in a therapeutically effective amount and in a form that is substantially non-absorbable by a gastrointestinal system of the mare; and
a pharmaceutically acceptable carrier for delivering the at least one gallium salt to a natural orifice, throat or lungs of the mare, the drug delivery system has an effect of decreasing the concentration of R. equi in the mare's feces, and
the drug delivery system is administered within a predetermined time range prior to an anticipated date of foaling for the mare.

### Claim 8 (depends on 7)

The method of claim 7, wherein the predetermined time range is at least one day.

### Claim 9 (depends on 7)

The method of claim 7, wherein the predetermined time range is at least three days.

### Claim 10 (depends on 7)

The method of claim 7, wherein the predetermined time range is at least five days.

### Claim 11 (depends on 7)

The method of claim 7, wherein the gallium salt is selected from a group consisting of gallium bromide, gallium chloride, gallium citrate, gallium fluoride, gallium iodide, gallium maltolate, gallium nitrate, gallium perchlorate, gallium sulfate, gallium phosphate, and gallium citrate.