# US 2014/0193520 A1 · Growth control of oral and superficial organisms using gallium compounds

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- Number: US 2014/0193520 A1
- Document ID: US20140193520A1
- Status: Published application
- Kind: A1
- Application number: 14/208,748
- Filed: 2014-03-13
- Published: 2014-07-10
- Earliest claimed: 2005-11-01
- Assignees: Mount Sinai School of Medicine
- Inventors: Daniel P. Perl; Sharon Moalem
- Web page: https://patentgrep.com/patent/US20140193520A1

## CPC

- A61K 33/24: Heavy metals; Compounds thereof
- A01N 55/02: containing metal atoms
- A01N 59/16: Heavy metals; Compounds thereof
- A23B 2/788: Inorganic compounds
- A23K 20/20: Inorganic substances, e.g. oligoelements
- A23L 33/16: Inorganic salts, minerals or trace elements
- A61K 8/19: containing inorganic ingredients
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 31/28: Compounds containing heavy metals
- A61L 2/16: using chemical substances
- A61L 2/18: Liquid substances
- A61L 12/088: {Heavy metals}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/02: for disorders of the vagina
- A61P 17/00: Drugs for dermatological disorders
- A61P 27/02: Ophthalmic agents
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q 11/02: Preparations for deodorising, bleaching or disinfecting dentures
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2800/58: Metal complex; Coordination compounds
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a gallium compound to an affected area. In particular, the present invention provides methods for treating or preventing dental caries, vaginal infections, skin infections, and so forth. Gallium compounds can be formulated as toothpaste, mouthwash, cream, ointment, gel, solution, eye drops, suppository, and the like. Furthermore, the invention provides methods for controlling microbial growth on environmental surfaces, including those of toothbrush, denture, dental retainer, contact lens, catheter, food stuff, and so forth. In addition, the present invention provides animal feeds which contain gallium compounds that promote the animal growth and prevent the animals from infections as well as protect consumers from post processing infections.

## Claims

### Claim 1

A method for controlling the growth of a microorganism on a skin surface of a subject, comprising:
applying a therapeutically effective amount of a gallium compound to the skin surface, thereby controlling the growth of the microorganism.

### Claim 2 (depends on 1)

The method of claim 1, wherein the gallium compound is formulated as a cream, lotion, solution, spray, aerosol, ointment, gel, or is formulated for slow diffusion.

### Claim 3 (depends on 1)

The method of claim 1, wherein the gallium compound is selected from the group consisting of: gallium nitrate, gallium maltolate, gallium citrate, gallium phosphate, gallium chloride, gallium fluoride, gallium carbonate, gallium formate, gallium acetate, gallium sulfate, gallium tartrate, gallium oxalate, gallium oxide, and gallium complexes including gallium pyrones, gallium pyridones, gallium oximes, gallium-bound proteins, and gallium-bound siderophores.

### Claim 4 (depends on 1)

The method of claim 1, wherein the microorganism is selected from the group consisting of: a species of Staphylococcus; Group A streptococci; a species of Enterococcus; Pseudomonas aeruginosa; Candida albicans; a species of Microsporon; a species of Trichophyton; a species of Pasteurella; a species of Capnocytophaga, a species of Klebsiella; and a species of Vibrio.

### Claim 5 (depends on 1)

The method of claim 1, wherein the microorganism is drug resistant.

### Claim 6 (depends on 5)

The method of claim 5, wherein the drug resistant microorganism is methicillin-resistant Staphylococcus aureus (MRSA), or vancomycin-resistant Enterococcus faecalis (VRE).

### Claim 7 (depends on 1)

The method of claim 1, wherein the subject is a human subject or a veterinary subject.

### Claim 8

A method for treating or preventing an infection on a skin surface of a subject, comprising:
applying a therapeutically effective amount of a gallium compound to the skin surface, thereby preventing or treating the infection.

### Claim 9 (depends on 8)

The method of claim 8, wherein the gallium compound is formulated as a cream, lotion, solution, spray, aerosol, ointment, gel, or is formulated for slow diffusion.

### Claim 10 (depends on 8)

The method of claim 8, wherein the gallium compound is applied to the skin of the subject on or embedded in a bandage or wound dressing.

### Claim 11 (depends on 8)

The method of claim 8, wherein the gallium compound is selected from the group consisting of: gallium nitrate, gallium maltolate, gallium citrate, gallium phosphate, gallium chloride, gallium fluoride, gallium carbonate, gallium formate, gallium acetate, gallium sulfate, gallium tartrate, gallium oxalate, gallium oxide, and gallium complexes including gallium pyrones, gallium pyridones, gallium oximes, gallium-bound proteins, and gallium-bound siderophores.

### Claim 12 (depends on 8)

The method of claim 8, wherein the microorganism is selected from the group consisting of: a species of Staphylococcus; Group A streptococci; a species of Enterococcus; Pseudomonas aeruginosa; Candida albicans; a species of Microsporon; a species of Trichophyton; a species of Pasteurella; a species of Capnocytophaga, a species of Klebsiella; and a species of Vibrio.

### Claim 13 (depends on 8)

The method of claim 8, wherein the microorganism is drug resistant.

### Claim 14 (depends on 13)

The method of claim 13, wherein the drug resistant microorganism is methicillin-resistant Staphylococcus aureus (MRSA), or vancomycin-resistant Enterococcus faecalis (VRE).

### Claim 15

A method for disinfecting a skin surface of a subject, comprising:
applying a therapeutically effective amount of a gallium compound to the skin surface, thereby disinfecting the skin surface.

### Claim 16 (depends on 15)

The method of claim 15, wherein the gallium compound is formulated as a cream, lotion, solution, spray, aerosol, ointment, gel, or is formulated for slow diffusion.

### Claim 17 (depends on 15)

The method of claim 15, wherein the gallium compound is applied as soap, shampoo, or hand disinfectant.

### Claim 18 (depends on 15)

The method of claim 15, wherein the gallium compound is selected from the group consisting of: gallium nitrate, gallium maltolate, gallium citrate, gallium phosphate, gallium chloride, gallium fluoride, gallium carbonate, gallium formate, gallium acetate, gallium sulfate, gallium tartrate, gallium oxalate, gallium oxide, and gallium complexes including gallium pyrones, gallium pyridones, gallium oximes, gallium-bound proteins, and gallium-bound siderophores.

### Claim 19 (depends on 15)

The method of claim 15, wherein the microorganism is drug resistant.

### Claim 20 (depends on 19)

The method of claim 19, wherein the drug resistant microorganism is methicillin-resistant Staphylococcus aureus (MRSA), or vancomycin-resistant Enterococcus faecalis (VRE).