# US 2014/0193516 A1 · Methods for treating glucose metabolic disorders

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- Number: US 2014/0193516 A1
- Document ID: US20140193516A1
- Status: Published application
- Kind: A1
- Application number: 14/209,214
- Filed: 2014-03-13
- Published: 2014-07-10
- Earliest claimed: 2010-04-12
- Assignees: ESM Holdings, LLC
- Inventors: Kevin Ruff
- Web page: https://patentgrep.com/patent/US20140193516A1

## CPC

- A61K 35/57: Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
- A61K 31/7008: Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A61K 31/726: Glycosaminoglycans, i.e. mucopolysaccharides (chondroitin sulfate, dermatan sulfate A61K31/737)
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 5/50: for increasing or potentiating the activity of insulin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

In one aspect, the invention relates to methods for treating a disease or condition associated with abnormal glucose metabolism. In another aspect, the invention relates to a method for reducing incidence or progression of insulin-dependent diabetes mellitus. The methods include orally administering to a mammal in need thereof an effective amount of a composition, which includes a naturally occurring material derived from eggshell, eggshell membrane, or a combination thereof.

## Claims

### Claim 1

A method for treating a disease or condition associated with abnormal glucose metabolism, said method comprising orally administering to a mammal in need thereof an effective amount of a composition comprising powdered eggshell membrane.

### Claim 2 (depends on 1)

The method of claim 1, wherein the disease or condition is insulin resistance.

### Claim 3 (depends on 1)

The method of claim 1, wherein the disease or condition is glucose intolerance

### Claim 4 (depends on 1)

The method of claim 1, wherein the disease or condition is glucose non-responsiveness.

### Claim 5

(canceled)

### Claim 6 (depends on 1)

The method of claim 1, wherein the effective amount is effective to achieve at least a 0.2 percentage point decrease in hemoglobin A1c.

### Claim 7 (depends on 1)

The method of claim 1, wherein the effective amount is effective to achieve at least a 1 percentage point decrease in hemoglobin A1c.

### Claim 8 (depends on 1)

The method of claim 1, wherein the effective amount is effective to achieve at least a 2 percentage point decrease in hemoglobin A1c.

### Claim 9 (depends on 1)

The method of claim 1, wherein the effective amount is effective to achieve at least a 3 percentage point decrease in hemoglobin A1c.

### Claim 10 (depends on 1)

The method of claim 1, wherein the effective amount is effective to decrease a fasting blood glucose concentration in said mammal by at least 5 mg/dL.

### Claim 11 (depends on 1)

The method of claim 1, wherein the effective amount is effective to decrease a fasting blood glucose concentration in said mammal by at least 10 mg/dL.

### Claim 12 (depends on 1)

The method of claim 1, wherein the effective amount is effective to decrease a fasting blood glucose concentration in said mammal by at least 20 mg/dL.

### Claim 13

(canceled)

### Claim 14

(canceled)

### Claim 15

(canceled)

### Claim 16 (depends on 1)

The method of claim 1, wherein the naturally occurring material is water soluble.

### Claim 17 (depends on 1)

The method of claim 1, wherein the naturally occurring material is water insoluble.

### Claim 18 (depends on 1)

The method of claim 1, wherein the composition comprising powdered eggshell membrane comprises the following in weight percent:
a. about 0.25 to about 5 wt % hexosamine;
b. about 0.3 to about 3 wt % glycosaminoglycan;
c. about 0.5 to about 5 wt % hyaluronic acid;
d. about 0.01 to about 2 wt % sialic acid; and/or
e. about 5 to about 20 wt % collagen.

### Claim 19

(canceled)

### Claim 20

(canceled)

### Claim 21

(canceled)

### Claim 22

(canceled)

### Claim 23 (depends on 1)

The method of claim 1, wherein the mammal is insulin-dependent.

### Claim 24 (depends on 1)

The method of claim 1, wherein the mammal has a fasting blood glucose concentration at least 100 mg/dL and at most 125 mg/dL.

### Claim 25

(canceled)